In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus
Mem. Inst. Oswaldo Cruz
;
102(4): 469-472, June 2007. tab
Article
in English
| LILACS
| ID: lil-454798
ABSTRACT
Peptides with broad-spectrum antimicrobial activity, known as antimicrobial peptides, have been isolated from distinct organisms. This paper describes the in vitro evaluation of the cytotoxicity and antiviral activity of nine peptides with different structures and origins against herpes simplex virus type 1, human adenovirus respiratory strain, and rotavirus SA11. Most of the evaluated peptides presented antiviral activity but they were only active near cytotoxic concentrations. Nevertheless, these results seem promising, and further modifications on the peptide's structures may improve their selectivity and reduce their cytotoxicity.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Antiviral Agents
/
Adenoviridae
/
Herpesvirus 1, Human
/
Rotavirus
/
Antimicrobial Cationic Peptides
Limits:
Animals
/
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2007
Type:
Article
/
Project document
Affiliation country:
Brazil
/
France
Institution/Affiliation country:
CNRS-Université de Montpellier II/FR
/
Universidade Federal de Santa Catarina/BR
Similar
MEDLINE
...
LILACS
LIS