Perspectives in the control of infectious diseases by transgenic mosquitoes in the post-genomic era: a review
Mem. Inst. Oswaldo Cruz
;
102(4): 425-433, June 2007.
Article
in English
| LILACS
| ID: lil-454803
ABSTRACT
Arthropod-borne diseases caused by a variety of microorganisms such as dengue virus and malaria parasites afflict billions of people worldwide imposing major economic and social burdens. Despite many efforts, vaccines against diseases transmitted by mosquitoes, with the exception of yellow fever, are not available. Control of such infectious pathogens is mainly performed by vector management and treatment of affected individuals with drugs. However, the numbers of insecticide-resistant insects and drug-resistant parasites are increasing. Therefore, inspired in recent years by a lot of new data produced by genomics and post-genomics research, several scientific groups have been working on different strategies to control infectious arthropod-borne diseases. This review focuses on recent advances and perspectives towards construction of transgenic mosquitoes refractory to malaria parasites and dengue virus transmission.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Animals, Genetically Modified
/
Mosquito Control
/
Insect Vectors
/
Culicidae
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2007
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade de Medicina de Marília/BR
/
Universidade de São Paulo/BR
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