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Perineural invasion by transitional cell carcinoma of the bladder in patients submitted to radical cystectomy: what is the prognostic value?
Antunes, Alberto A; Nesrallah, Luciano J; Dall'oglio, Marcos F; Crippa, Alexandre; Nesrallah, Adriano J; Paranhos, Mario; Leite, Katia R; Srougi, Miguel.
  • Antunes, Alberto A; University of Sao Paulo. Medical School. Division of Urology. Sao Paulo. BR
  • Nesrallah, Luciano J; University of Sao Paulo. Medical School. Division of Urology. Sao Paulo. BR
  • Dall'oglio, Marcos F; University of Sao Paulo. Medical School. Division of Urology. Sao Paulo. BR
  • Crippa, Alexandre; University of Sao Paulo. Medical School. Division of Urology. Sao Paulo. BR
  • Nesrallah, Adriano J; University of Sao Paulo. Medical School. Division of Urology. Sao Paulo. BR
  • Paranhos, Mario; University of Sao Paulo. Medical School. Division of Urology. Sao Paulo. BR
  • Leite, Katia R; University of Sao Paulo. Medical School. Division of Urology. Sao Paulo. BR
  • Srougi, Miguel; University of Sao Paulo. Medical School. Division of Urology. Sao Paulo. BR
Int. braz. j. urol ; 33(2): 161-166, Mar.-Apr. 2007. ilus, graf
Article in English | LILACS | ID: lil-455589
ABSTRACT

OBJECTIVE:

Determine the prognostic value of perineural invasion (PNI) in patients with transitional cell carcinoma (TCC) of the bladder treated with radical cystectomy. MATERIALS AND

METHODS:

From January 1993 to January 2005, 113 people were selected from 153 patients with TCC of the bladder treated with radical cystectomy. The association between the presence of PNI and other pathologic characteristics were analyzed through Fisher exact test. The Kaplan-Meier method was utilized to assess the survival curve and the statistical significance was determined by the Breslow test. The multivariate analysis was performed through the Cox regression model.

RESULTS:

The PNI was identified in 10 (8.8 percent) of the 113 patients. This variable significantly related to the microvascular invasion and to tumor staging. The mean segment after surgery was 31.7 ± 28.5 months. Recurrence occurred in 5 (50 percent) and in 41 (39.8 percent) patients (p = 0.363) and mortality occurred in 2 (20 percent) and 22 (21.9 percent) patients (p = 0.606) with or without PNI respectively. In Cox regression analysis, patients with PNI presented with 1.53 times (IC 95 percent 0.60 to 3.91; p = 0.371) and 1.60 times (IC 95 percent 0.37 to 6.95; p = 0.532) the risk of recurrence and mortality when compared to patients without PNI.

CONCLUSIONS:

The PNI does not constitute an independent variable of disease-free and cancer specific survival in patients with TCC of the bladder treated with radical cystectomy.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Urinary Bladder Neoplasms / Carcinoma, Transitional Cell / Peripheral Nervous System Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2007 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of Sao Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Urinary Bladder Neoplasms / Carcinoma, Transitional Cell / Peripheral Nervous System Type of study: Etiology study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2007 Type: Article Affiliation country: Brazil Institution/Affiliation country: University of Sao Paulo/BR