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Avaliação laboratorial da toxicidade molecular em eritrócitos talassêmicos / Laboratorial evaluation of molecular toxicity in thalassemic erythrocytes
Naoum, Paulo Cesar; Querino, Sheldon S. S; Cury, Nathália M; Toledo, Cristiane G; Naoum, Flávio Augusto.
  • Naoum, Paulo Cesar; Academia de Ciência e Tecnologia de São José do Rio Preto. São José do Rio Preto. BR
  • Querino, Sheldon S. S; Academia de Ciência e Tecnologia de São José do Rio Preto. São José do Rio Preto. BR
  • Cury, Nathália M; Academia de Ciência e Tecnologia de São José do Rio Preto. São José do Rio Preto. BR
  • Toledo, Cristiane G; Academia de Ciência e Tecnologia de São José do Rio Preto. São José do Rio Preto. BR
  • Naoum, Flávio Augusto; Academia de Ciência e Tecnologia de São José do Rio Preto. São José do Rio Preto. BR
Rev. bras. hematol. hemoter ; 28(4): 301-302, out.-dez. 2006. ilus, tab
Article in Portuguese | LILACS | ID: lil-456243
ABSTRACT
Oxygen-derived free radical damage is associated with the molecular toxicity of hemoglobin. Especially in thalassemia syndromes, this toxicity has a relationship with "free" alpha globin concentrations. This study of beta thalassemia trait blood samples from 39 individuals shows that the evaluation of methemoglobin is a sensitive method of indicating molecular toxicity and the superoxide dismutase concentration revealing the intensity of oxidative stress of this process.
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Full text: Available Index: LILACS (Americas) Main subject: Thalassemia / Beta-Thalassemia / Clinical Laboratory Techniques / Erythrocytes Type of study: Diagnostic study Limits: Humans Language: Portuguese Journal: Rev. bras. hematol. hemoter Journal subject: Hematology Year: 2006 Type: Article Affiliation country: Brazil Institution/Affiliation country: Academia de Ciência e Tecnologia de São José do Rio Preto/BR

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Full text: Available Index: LILACS (Americas) Main subject: Thalassemia / Beta-Thalassemia / Clinical Laboratory Techniques / Erythrocytes Type of study: Diagnostic study Limits: Humans Language: Portuguese Journal: Rev. bras. hematol. hemoter Journal subject: Hematology Year: 2006 Type: Article Affiliation country: Brazil Institution/Affiliation country: Academia de Ciência e Tecnologia de São José do Rio Preto/BR