Relación entre niveles de carbamazepina en saliva y plasma: Estudio piloto / Saliva and plasma levels of carbamazepine have a poor correlation: a pilot study
Rev. méd. Chile
;
135(3): 335-340, mar. 2007. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-456619
ABSTRACT
Abstract Carbamazepine is one of the most commonly used anticonvulsants for the treatment of epilepsy and its plasma concentrations must be monitored periodically to obtain a useful and safe clinical effect. There is not a good relationship between the dose of the carbamazepine and their effects in humans, but the effects of this drug have been well correlated with its plasma levels. Aim:
To measure the correlation between plasma and saliva levels of carbamazepine in children with epilepsy. Material andMethods:
Saliva and plasma levels of carbamazepine were measured by using instrumental planar chromatography in 11 epileptic children aged 8 to 15 years treated with the drug for at least six months.Results:
The mean saliva/plasma ratio was 0.18±0.05 and the mean of carbamazepine concentration in saliva, expressed as a percentage of concentrations in plasma, was 17.97±5.40. There was a poor linear correlation (r =0.37) between the concentrations of carbamazepine in both fluids.Conclusions:
In this group of epileptic children the correlation between saliva and plasma carbamazepine levels was weak.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Saliva
/
Carbamazepine
/
Epilepsy
/
Anticonvulsants
Limits:
Adolescent
/
Child
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2007
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Las Higueras/CL
/
Universidad de Concepción/CL
Similar
MEDLINE
...
LILACS
LIS