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Resposta neuroendócrina aguda ao citalopram e resposta terapêutica no transtorno obsessivo-complusivo / Acute neuroendocrine response to citalopram and therapeutic response in obsessive-compulsive disorder
São Paulo; s.n; 2007. 131 p. ilus, tab, graf.
Thesis in Portuguese | LILACS | ID: lil-456636
RESUMO
Testes provocativos com drogas serotonérgicas mostraram resultados conflitantes no TOC. O objetivo deste estudo foi comparar a atividade serotonérgica em pacientes com TOC resistente e respondedor ao tratamento com inibidores de recaptura de serotonina e voluntários saudáveis. Foram estudados 30 sujeitos em cada grupo. Cada um recebeu 20 mg de citalopram intravenoso. Foram dosados prolactina, cortisol, hormônio de crescimento e serotonina periféricos a cada 20 minutos por 180 minutos. Não houve diferenças nas concentrações de serotonina e de hormônio de crescimento. A droga induziu um pico maior de prolactina no grupo Controle do que nos grupos Resistentes e Respondedores (p<0,05). A secreção de cortisol mostrou-se atenuada apenas no grupo Resistentes (p<0,05), sugerindo maior disfunção serotonérgica neste grupo...
ABSTRACT
Serotonergic pharmacological challenge tests have conflictant results in OCD. The aim of this study was to compare the serotonergic activity in serotonin reuptake inhibitors treatment resistant and responsive OCD patients and healthy volunteers. Thirty subjects were included in each group. Each one has received 20 mg of intravenous citalopram. Prolactin, cortisol, growth hormone and serotonin were determined peripherically at 20 minutes intervals for 180 minutes. No changes were observed either in serotonin or growth hormone concentration. Citalopram has induced an increase in prolactin secretion in the Control group, not observed in Resistant and Responsive groups (p<0.05). The cortisol response to citalopram was attenuated only in the Resistants (p<0.05), suggesting a more disrupted serotonergic transmission in this group...
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Citalopram / Selective Serotonin Reuptake Inhibitors / Obsessive-Compulsive Disorder Type of study: Prognostic study Limits: Adult / Female / Humans / Male Language: Portuguese Year: 2007 Type: Thesis

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Full text: Available Index: LILACS (Americas) Main subject: Citalopram / Selective Serotonin Reuptake Inhibitors / Obsessive-Compulsive Disorder Type of study: Prognostic study Limits: Adult / Female / Humans / Male Language: Portuguese Year: 2007 Type: Thesis