Duffy blood group genotypes among African-Brazilian communities of the Amazon region
Genet. mol. res. (Online)
;
6(1): 166-172, 2007. tab
Article
in English
| LILACS
| ID: lil-456762
ABSTRACT
Duffy blood group genotype was studied in 95 unrelated subjects from four African-Brazilian communities of the Amazon region Trombetas, Pitimandeua, Curiaú, and Mazagão Velho. Genotyping was performed using an allele-specific primer polymerase chain reaction technique for determining the three major alleles at FY blood group, and as expected, FY*O allele was the most common one, with frequencies ranging from 56.4% in Mazagão Velho to 72.2% in Pitimandeua, whereas the FY*O/FY*O genotype was found with frequencies between 32.3% in Mazagão Velho and 58.8% in Curiaú. Genotype and allele distributions in the four Amazonian communities are consistent with a predominantly African origin with some degree of local differentiation and admixture with people of Caucasian ancestry and/or Amerindians. These results reveal that the impact of the FY*O/FY*O genotype on the transmission and endemicity of the vivax malaria deserves to be investigated in full detail in an attempt to identify the contribution of host biological factors and explain the non-homogeneous prevalence of malaria in the region expressed by its different levels of exposure
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Black People
/
Duffy Blood-Group System
/
Gene Frequency
Type of study:
Prognostic study
/
Risk factors
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Genet. mol. res. (Online)
Journal subject:
Molecular Biology
/
Genetics
Year:
2007
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Pará/BR
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