Your browser doesn't support javascript.
loading
131I-induced changes in rat thyroid gland function
Torlak, V; Zemunik, T; Modun, D; Capkun, V; Pesutic-Pisac, V; Markotic, A; Pavela-Vrancic, M; Stanicic, A.
  • Torlak, V; Clinical Hospital Split. Department of Nuclear Medicine. Split. HR
  • Zemunik, T; University of Split. Department of Medical Biology. Split. HR
  • Modun, D; University of Split. Department of Pharmacology. Split. HR
  • Capkun, V; Clinical Hospital Split. Department of Nuclear Medicine. Split. HR
  • Pesutic-Pisac, V; Clinical Hospital Split. Department of Pathology. Split. HR
  • Markotic, A; University of Split. School of Medicine. Department of Biochemistry. Split. HR
  • Pavela-Vrancic, M; University of Split. Department of Chemistry. Split. HR
  • Stanicic, A; Clinical Hospital Split. Department of Nuclear Medicine. Split. HR
Braz. j. med. biol. res ; 40(8): 1087-1094, Aug. 2007. ilus, graf, tab
Article in English | LILACS | ID: lil-456802
ABSTRACT
Therapeutic doses of 131I administered to thyrotoxic patients may cause thyroid failure. The present study used a rat model to determine thyroid function after the administration of different doses of 131I (64-277 µCi). Thirty male Fisher rats in the experimental group and 30 in the control group (untreated) were followed for 6 months. The animals were 4 months old at the beginning of the experiment and were sacrificed at an age of 9 months. Hormone concentration was determined before 131I administration (4-month-old animals) and three times following 131I administration, when the animals were 7, 8, and 9 months old. The thyroid glands were removed and weighed, their volume was determined and histopathological examination was performed at the end of the experiment. Significant differences in serum triiodothyronine and thyroid-stimulating hormone concentration, measured at the age of 7, 8, and 9 months, were found in the experimental group. During aging of the animals, the concentration of thyroxin fell from 64.8 ± 8.16 to 55.0 ± 6.1 nM in the control group and from 69.4 ± 6.9 to 25.4 ± 3.2 nM in the experimental group. Thyroid gland volume and weight were significantly lower in the experimental than in the control group. Thyroid glands from the experimental group showed hyaline thickness of the blood vessel wall, necrotic follicles, a strong inflammatory reaction, and peeling of necrotic cells in the follicles. In conclusion, significant differences in hormone levels and histopathological findings indicated prolonged hypothyroidism after 131I administration to rats, which was not 131I dose dependent.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Thyroid Gland / Thyroxine / Triiodothyronine / Thyrotropin / Iodine Radioisotopes Type of study: Prognostic study Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2007 Type: Article / Project document Affiliation country: Croatia Institution/Affiliation country: Clinical Hospital Split/HR / University of Split/HR

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: LILACS (Americas) Main subject: Thyroid Gland / Thyroxine / Triiodothyronine / Thyrotropin / Iodine Radioisotopes Type of study: Prognostic study Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2007 Type: Article / Project document Affiliation country: Croatia Institution/Affiliation country: Clinical Hospital Split/HR / University of Split/HR