Bioactivity of two Turkish endemic Centaurea species, and their major constituents
Rev. bras. farmacogn
;
17(2): 155-159, abr.-jun. 2007. tab, ilus
Article
in English
| LILACS
| ID: lil-456982
ABSTRACT
The antioxidant activity, general toxicity and cytotoxicity of the methanol extracts of Centaurea urvillei subs. armata and C. mucronifera have been assessed, respectively, by the DPPH assay, the brine shrimp lethality and the MTT cytotoxicity assays. The reversed-phase HPLC analysis of the methanol extracts afforded two bioactive dibenzylbutyrolactone-type lignans, matairesinoside (1) and arctiin (2). The structures of these lignans were elucidated by comprehensive spectroscopic analyses as well as by the direct comparison of experimental data with respective literature data.
RESUMO
A atividade antioxidante, a toxicidade geral e a citotoxidade dos extratos metanólicos de Centaurea urvillei subs. armata e C. mucronifera foram analisados, respectivamente, pelo ensaio DPPH e pelos ensaios de letalidade de Artemia salina e de citotoxidade MTT. A análise dos extratos metanólicos em CLAE de fase reversa apresentou duas lignanas biotivas do tipo dibenzilbutirolactona, matairesinosídeo (1) e arctiina (2). As estruturas destas lignanas foram elucidadas através de análises espectroscópicas completas bem como por comparação direta dos dados experimentais com os respectivos dados da literatura.
Full text:
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Index:
LILACS (Americas)
Main subject:
Artemia
/
Plant Extracts
/
Lignans
/
Asteraceae
/
Centaurea
Language:
English
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2007
Type:
Article
Affiliation country:
Bangladesh
/
Turkey
/
United kingdom
Institution/Affiliation country:
Canakkale Onsekiz Mart University/TR
/
The Robert Gordon University/GB
/
University of Aberdeen/GB
/
University of Dhaka/BD
/
University of Ulster/GB
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