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The impact of dengue on liver function as evaluated by aminotransferase levels
Souza, Luiz José de; Nogueira, Rita Maria Ribeiro; Soares, Leandro Cordeiro; Soares, Carlos Eduardo Cordeiro; Ribas, Bruno Fernandes; Alves, Felipe Pinto; Vieira, Fabíola Rodrigues; Pessanha, Felipe Eulálio Baldi.
  • Souza, Luiz José de; Dengue Reference Center. Campos dos Goytacazes. BR
  • Nogueira, Rita Maria Ribeiro; FIOCRUZ. Oswaldo Cruz Institute. Department of Virology. Campos dos Goytacazes. BR
  • Soares, Leandro Cordeiro; Dengue Reference Center. Campos dos Goytacazes. BR
  • Soares, Carlos Eduardo Cordeiro; Dengue Reference Center. Campos dos Goytacazes. BR
  • Ribas, Bruno Fernandes; Dengue Reference Center. Campos dos Goytacazes. BR
  • Alves, Felipe Pinto; Dengue Reference Center. Campos dos Goytacazes. BR
  • Vieira, Fabíola Rodrigues; Dengue Reference Center. Campos dos Goytacazes. BR
  • Pessanha, Felipe Eulálio Baldi; Dengue Reference Center. Campos dos Goytacazes. BR
Braz. j. infect. dis ; 11(4): 407-410, Aug. 2007. graf, tab
Article in English | LILACS | ID: lil-460701
Responsible library: BR1.1
ABSTRACT
The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels grade A - normal enzyme levels; grade B - increased levels of at least one of the enzymes; grade C - increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D - acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1 percent had abnormal aminotransferase levels 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9 percent of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Aspartate Aminotransferases / Dengue / Alanine Transaminase / Liver Type of study: Practice guideline Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2007 Type: Article Affiliation country: Brazil Institution/Affiliation country: Dengue Reference Center/BR / FIOCRUZ/BR
Full text: Available Index: LILACS (Americas) Main subject: Aspartate Aminotransferases / Dengue / Alanine Transaminase / Liver Type of study: Practice guideline Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2007 Type: Article Affiliation country: Brazil Institution/Affiliation country: Dengue Reference Center/BR / FIOCRUZ/BR