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Chronic inflammatory demyelinating polyradiculoneuropathy in chronic graft-versus-host disease following allogeneic hematopoietic stem cell transplantation: case report
Lorenzoni, Paulo José; Scola, Rosana Herminia; Carsten, Ana Lucila Moreira; Trentin, Ana Paula; Teive, Hélio A. G; Pasquini, Ricardo; Werneck, Lineu C.
  • Lorenzoni, Paulo José; Federal University of Paraná. Hospital de Clínicas. Internal Medicine Department. Neurology and Bone Marrow Transplantation Services. Curitiba. BR
  • Scola, Rosana Herminia; Federal University of Paraná. Hospital de Clínicas. Internal Medicine Department. Neurology and Bone Marrow Transplantation Services. Curitiba. BR
  • Carsten, Ana Lucila Moreira; Federal University of Paraná. Hospital de Clínicas. Internal Medicine Department. Neurology and Bone Marrow Transplantation Services. Curitiba. BR
  • Trentin, Ana Paula; Federal University of Paraná. Hospital de Clínicas. Internal Medicine Department. Neurology and Bone Marrow Transplantation Services. Curitiba. BR
  • Teive, Hélio A. G; Federal University of Paraná. Hospital de Clínicas. Internal Medicine Department. Neurology and Bone Marrow Transplantation Services. Curitiba. BR
  • Pasquini, Ricardo; Federal University of Paraná. Hospital de Clínicas. Internal Medicine Department. Neurology and Bone Marrow Transplantation Services. Curitiba. BR
  • Werneck, Lineu C; Federal University of Paraná. Hospital de Clínicas. Internal Medicine Department. Neurology and Bone Marrow Transplantation Services. Curitiba. BR
Arq. neuropsiquiatr ; 65(3a): 700-704, set. 2007. tab
Article in English | LILACS | ID: lil-460815
ABSTRACT
The chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an unusual but important complication of hematopoietic stem cell transplantation (HSCT) rarely reported to date. We describe a 17-year-old woman with a diagnosis of acute myeloid leukemia due to Fanconi's anemia who was submitted to allogeneic HSCT and developed CIDP as part of graft-versus-host disease. Investigation showed high cerebrospinal fluid protein; electrophysiological studies revealed sensory-motor demyelinating polyradiculoneuropathy; muscle and nerve biopsy were compatible with CIDP.
RESUMO
A polirradiculoneuropatia desmielinizante inflamatória crônica (CIDP) é uma incomum, porém, importante complicação do transplante de células hematopoiéticas (HSCT) raramente relatada até a data. Nós descrevemos uma mulher de 17 anos com diagnóstico de leucemia mielóide aguda por anemia de Fanconi que foi submetida à HSCT e desenvolveu CIDP como parte da doença do enxerto contra o hospedeiro. A investigação mostrou elevação na proteína no líquor; estudo eletrofisiológico revelando polirradiculoneuropatia desmielinizante sensitivo-motora; e biópsia de músculo e nervo compatível com CIDP.
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Full text: Available Index: LILACS (Americas) Main subject: Hematopoietic Stem Cell Transplantation / Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Graft vs Host Disease Limits: Adolescent / Female / Humans Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2007 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraná/BR

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Full text: Available Index: LILACS (Americas) Main subject: Hematopoietic Stem Cell Transplantation / Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Graft vs Host Disease Limits: Adolescent / Female / Humans Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2007 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Paraná/BR