Ambient particulate air pollution from vehicles promotes lipid peroxidation and inflammatory responses in rat lung
Braz. j. med. biol. res
;
40(10): 1353-1359, Oct. 2007. graf, tab
Article
in English
| LILACS
| ID: lil-461363
ABSTRACT
Oxidative stress plays a major role in the pathogenesis of particle-dependent lung injury. Ambient particle levels from vehicles have not been previously shown to cause oxidative stress to the lungs. The present study was conducted to a) determine whether short-term exposure to ambient levels of particulate air pollution from vehicles elicits inflammatory responses and lipid peroxidation in rat lungs, and b) determine if intermittent short-term exposures (every 4 days) induce some degree of tolerance. Three-month-old male Wistar rats were exposed to ambient particulate matter (PM) from vehicles (N = 30) for 6 or 20 continuous hours, or for intermittent (5 h) periods during 20 h for 4 consecutive days or to filtered air (PM <10 mum; N = 30). Rats continuously breathing polluted air for 20 h (P-20) showed a significant increase in the total number of leukocytes in bronchoalveolar lavage compared to control (C-20 2.61 x 105 ± 0.51;P-20 5.01 x 105 ± 0.81; P < 0.05) and in lipid peroxidation ([MDA] nmol/mg protein C-20 0.148 ± 0.01; P-20 0.226 ± 0.02; P < 0.05). Shorter exposure (6 h) and intermittent 5-h exposures over a period of 4 days did not cause significant changes in leukocytes. Lipid damage resulting from 20-h exposure to particulate air pollution did not cause a significant increase in lung water content. These data suggest oxidative stress as one of the mechanisms responsible for the acute adverse respiratory effects of particles, and suggest that short-term inhalation of ambient particulate air pollution from street with high automobile traffic represents a biological hazard.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Vehicle Emissions
/
Lipid Peroxidation
/
Air Pollutants
/
Particulate Matter
/
Inflammation
/
Lung
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2007
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Faculdade Federal de Ciências Médicas de Porto Alegre/BR
/
Universidade de São Paulo/BR
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