Interleukin-15: its role in microbial infections
J. venom. anim. toxins incl. trop. dis
;
13(3): 562-575, 2007.
Article
in English
| LILACS, VETINDEX
| ID: lil-461644
ABSTRACT
Interleukin-15 (IL-15) is a pleiotropic cytokine which regulates the proliferation, survival and the secretory activities of many distinct cell types in the body. This cytokine is produced by macrophages and many other cell types in response to infectious agents; it controls growth and differentiation of T and B lymphocytes, activation of Natural Killer (NK) and phagocytic cells, and contributes to the homeostasis of the immune system. The present review focuses on the biological and modulatory effects of IL-15 in microbial infections and shows that this cytokine may play a role in the host defense against infections by inducing activation of effector cells from both innate and adaptive immune system.(AU)
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Cytokines
/
Interleukin-15
/
Immune System
/
Infections
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Year:
2007
Type:
Article
Institution/Affiliation country:
São Paulo State University/BR
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