Inflammation and clinical repercussions of pleurodesis induced by intrapleural talc administration
Clinics
;
62(5): 627-634, 2007. ilus
Article
in English
| LILACS
| ID: lil-465121
ABSTRACT
Although reports on pleurodesis date back to the beginning of the 20th century, the search for the ideal sclerosing agent is ongoing. Several agents have been studied and used, but talc continues to be the most popular. However, potentially harmful systemic side effects have been associated with talc pleurodesis. In this article we discuss the likely mechanisms of pleural inflammation and pleurodesis with emphasis on the systemic response due to the instillation of talc into the pleural space.
RESUMO
Apesar dos relatos sobre pleurodese remontarem ao início do século XX, ainda hoje se busca o agente esclerosante ideal. Diversos agentes foram estudados e utilizados, mas o talco é considerado o mais popular. No entanto, efeitos sistêmicos potencialmente tóxicos tem sido associados à pleurodese pelo talco. Neste artigo discutimos os prováveis mecanismos de inflamação pleural e pleurodese, com ênfase na resposta sistêmica produzida pela instilação intrapleural de talco.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Talc
/
Pleurodesis
/
Inflammation
Limits:
Animals
/
Humans
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2007
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of São Paulo/BR
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