Análisis del resultado de pruebas hepáticas en pacientes psoriáticos tratados con metotrexato: Estudio retrospectivo / Serum liver tests in patients treated with methotrexate: A retrospective analysis
Rev. méd. Chile
; 135(8): 1002-1008, ago. 2007. tab
Article
in Es
| LILACS
| ID: lil-466482
Responsible library:
BR1.1
ABSTRACT
Background:
Methotrexate is one of the best systemic treatments for psoriasis. However it has significant adverse effects such as myelotoxicity and hepatotoxicity.Aim:
To evaluate serum liver test in psoríatic patients treated with methotrexate. Material andMethods:
Retrospective review of medical records of psoríatic patients treated with methotrexate between the years 2000 and 2005. All patients received a minimum of 7.5 mg weekly of methotrexate, for at íeast 4 weeks.Results:
Sixty three patients were included. Mean cumulative dose of methotrexate was 576 mg. Thirty two percent had alterations in liver tests, but only 9 percent had values that duplicated the upper limit of normal range of aminotransferases or alkaline phosphatases or a serum bilirubin over 2 mg/dl. We did not find a direct relationship between the dose of methotrexate and the magnitude of liver test alterations. Only one patient exceeded 1.5 g as cumulative dose. A liver biopsy performed to him, did not show signs of fibrosis.Conclusions:
This retrospective study does not show a direct relationship between weekly doses, cumulated dose and length of treatment with methotrexate, and the degree of alteration of serum liver tests.Key words
Full text:
1
Index:
LILACS
Main subject:
Psoriasis
/
Methotrexate
/
Dermatologic Agents
/
Chemical and Drug Induced Liver Injury
/
Liver
Type of study:
Observational_studies
Limits:
Female
/
Humans
/
Male
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
2007
Type:
Article