Estrés oxidativo e inflamación en insuficiencia cardiaca: Mecanismos de daño y alternativas terapéuticas / Oxidative stress and inflammation in heart failure: Mechanisms of damage and therapeutic alternatives
Rev. méd. Chile
;
135(8): 1056-1063, ago. 2007. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-466488
ABSTRACT
Despite advances in treatment, chronic heart failure still is associated with a poor prognosis and remains a leading cause of cardiovascular death. Cumulating evidence suggests that imbalances in redox state lead to a higher generation of reactive oxygen species. This phenomenon, along with pro-inflammatory cytokine activation and extra cellular matrix alterations with reactive fibrosis, play an important role in the pathogenesis and progression of heart failure, through the development of endothelial and myocardial dysfunction. The understanding of the underlying phenomena and the metabolic pathways involved will allow further development of therapies aiming to change the natural history of heart failure.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Endothelium, Vascular
/
Oxidative Stress
/
Evidence-Based Medicine
/
Heart Failure
/
Inflammation
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2007
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Dipreca/CL
/
Pontificia Universidad Católica de Chile/CL
/
Universidad de Chile/CL
Similar
MEDLINE
...
LILACS
LIS