Avances en la prevención de eventos tromboembólicos en pacientes con fibrilación auricular / Update on the prevention of thromboembolic phenomena in atrial fibrillation
Rev. méd. Chile
;
135(8): 1048-1055, ago. 2007. ilus
Article
in Spanish
| LILACS
| ID: lil-466497
ABSTRACT
Atrial fibrillation is the most common sustained arrhythmia in clinical practice and is associated to thromboembolic complications. Anticoagulation with vitamin K antagonists is clearly useful to reduce the incidence of emboli, but associated with important limitations. Therefore, there is an active search for medications that are more effective and simpler to prescribe and manage. Synthetic pentasaccharides of heparin such as idraparinux for parenteral use, showed promising results. Direct inhibitors of thrombin were also useful for the prevention of thromboembolism. However, they were withdrawn from the market due to potentially fatal adverse reactions. Other area of investigation has been the effectiveness of the combination of antiplatelet agents such as aspirin and clopidrogel. Although this combination is attractive, results of clinical trials must be awaited to have an opinion about its real usefulness. Finally, ieft atrial appendage transcatheter occlusion (PLAATO) is an effective and reasonably safe method for patients with contraindications for anticoagulation or those that continue to embolize despite well prescribed anticoagulation. The long term results of this intervention must also be awaited.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Atrial Fibrillation
/
Thromboembolism
/
Anticoagulants
Type of study:
Controlled clinical trial
/
Etiology study
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2007
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL
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