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Low expression of antigen-presenting and costimulatory molecules by lung cells from tuberculosis patients
Flores-Batista, V. C. S; Boechat, N; Lago, P. M; Lazzarini, L. C; Pessanha, L. R; Almeida, A. S; Mafort, T. T; Kritski, A. L; Ho, J. L; Lapa-e-Silva, J. R.
  • Flores-Batista, V. C. S; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Laboratório Multidisciplinar de Pesquisa. Rio de Janeiro. BR
  • Boechat, N; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Laboratório Multidisciplinar de Pesquisa. Rio de Janeiro. BR
  • Lago, P. M; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Laboratório Multidisciplinar de Pesquisa. Rio de Janeiro. BR
  • Lazzarini, L. C; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Laboratório Multidisciplinar de Pesquisa. Rio de Janeiro. BR
  • Pessanha, L. R; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Laboratório Multidisciplinar de Pesquisa. Rio de Janeiro. BR
  • Almeida, A. S; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Laboratório Multidisciplinar de Pesquisa. Rio de Janeiro. BR
  • Mafort, T. T; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Laboratório Multidisciplinar de Pesquisa. Rio de Janeiro. BR
  • Kritski, A. L; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Laboratório Multidisciplinar de Pesquisa. Rio de Janeiro. BR
  • Ho, J. L; Weill Medical College of Cornell University. Division of International Medicine and Infectious Diseases. New York. US
  • Lapa-e-Silva, J. R; Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Instituto de Doenças do Tórax. Laboratório Multidisciplinar de Pesquisa. Rio de Janeiro. BR
Braz. j. med. biol. res ; 40(12): 1671-1679, Dec. 2007. graf, tab
Article in English | LILACS | ID: lil-466737
ABSTRACT
Costimulatory and antigen-presenting molecules are essential to the initiation of T cell immunity to mycobacteria. The present study analyzed by immunocytochemistry, using monoclonal antibodies and alkaline phosphatase-anti-alkaline phosphatase method, the frequency of costimulatory (CD86, CD40, CD40L, CD28, and CD152) and antigen-presenting (MHC class II and CD1) molecules expression on human lung cells recovered by sputum induction from tuberculosis (TB) patients (N = 22) and non-TB controls (N = 17). TB cases showed a statistically significant lower percentage of HLA-DR+ cells than control subjects (21.9 ± 4.2 vs 50.0 ± 7.2 percent, P < 0.001), even though similar proportions of TB cases (18/22) and control subjects (16/17, P = 0.36) had HLA-DR-positive-stained cells. In addition, fewer TB cases (10/22) compared to control subjects (16/17) possessed CD86-expressing cells (P = 0.04; OR 0.05; 95 percentCI = 0.00-0.51), and TB cases expressed a lower percentage of CD86+ cells (P = 0.04). Moreover, TB patients with clinically limited disease (£1 lobe) on chest X-ray exhibited a lower percentage of CD86-bearing cells compared to patients with more extensive lung disease (>1 lobe) (P = 0.02). The lower expression by lung cells from TB patients of HLA-DR and CD86, molecules involved in antigen presentation and activation of T cells, may minimize T cell recognition of Mycobacterium tuberculosis, fostering an immune dysfunctional state and active TB.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Tuberculosis, Pulmonary / T-Lymphocytes / HLA-DR Antigens / Histocompatibility Antigens Class II / Antigens, CD / Antigen-Presenting Cells Type of study: Observational study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2007 Type: Article / Project document Affiliation country: Brazil / United States Institution/Affiliation country: Universidade Federal do Rio de Janeiro/BR / Weill Medical College of Cornell University/US

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Full text: Available Index: LILACS (Americas) Main subject: Tuberculosis, Pulmonary / T-Lymphocytes / HLA-DR Antigens / Histocompatibility Antigens Class II / Antigens, CD / Antigen-Presenting Cells Type of study: Observational study / Risk factors Limits: Adult / Female / Humans / Male Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2007 Type: Article / Project document Affiliation country: Brazil / United States Institution/Affiliation country: Universidade Federal do Rio de Janeiro/BR / Weill Medical College of Cornell University/US