Bacteria-induced apoptosis: an approach to bacterial pathogenesis
Braz. j. morphol. sci
;
23(1): 75-86, jan.-mar. 2006. ilus
Article
in English
| LILACS
| ID: lil-467601
ABSTRACT
Several pathogenic or opportunistic bacteria can induce or inhibit host cell apoptosis. The modulation of cellular pathways that results in the induction or delay of host cell apoptosis is an important mechanism of bacterial virulence. These processes can be mediated by various host cell signaling pathways that are subverted by the bacteria. Pathogens can activate apoptotic proteins such as caspases, inactivate anti-apoptotic proteins such as NFêB and mitogen-activated protein kinases, or up-regulate the endogenous receptor/ligand system that induces apoptosis, generally when the bacteria are bound to the host cell surface. Bacteria-induced apoptotic or anti-apoptotic processes are often related to the ability of the bacteria to reach the host tissues. However, since apoptosis is also involved in host defense mechanisms against infectious agents, this phenomenon apparently plays a central role in host-pathogen interactions.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Bacteria
/
Bacterial Infections
/
Cells
/
Apoptosis
/
Apoptosis Inducing Factor
Type of study:
Etiology study
Language:
English
Journal:
Braz. j. morphol. sci
Journal subject:
Anatomy
Year:
2006
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
State University of Campinas/BR
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