Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation
Biol. Res
;
40(2): 155-162, 2007. graf
Article
in English
| LILACS
| ID: lil-468186
ABSTRACT
The antioxidant effect of 5-Aminosalicylic acid (5-ASA) on copper-mediated LDL oxidation was followed either by the emitted chemiluminiscence (CL) or by UV-vis spectroscopy. 5-ASA addition extends the lag phase in a concentration-dependent manner without changes in the rate of the process in the autoaccelerated phase. The antioxidant behavior of 5-ASA was very similar to that of Trolox, a very efficient water soluble antioxidant. The copper-binding capacity of 5-ASA was evaluated by UV-visible spectroscopy. The addition of copper to a 5-ASA solution increases the absorbance at 332 nm and generates a new band at 298 nm. These changes in the UV-vis spectra indicate formation of a complex between 5-ASA and copper. However, LDL protection by 5-ASA is unrelated to its copper chelating capacity.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Copper
/
Aminosalicylic Acids
/
Lipoproteins, LDL
/
Antioxidants
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2007
Type:
Article
/
Project document
Affiliation country:
Chile
Institution/Affiliation country:
Pontificia Universidad Católica de Chile/CL
/
Universidad de Chile/CL
/
Universidad de Santiago de Chile/CL
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