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Redução da transmissão vertical durante o pré-natal de gestantes portadoras de HIV/AIDS / Reduction in the vertical transmission during the prenatal period of pregnant women affected by HIV/AIDS
Pinho Neto, Otávio Soares de; Oliveira, Marinete Madalena de.
  • Pinho Neto, Otávio Soares de; UFPB. Hospital Universitário Lauro Wanderley. João Pessoa. BR
  • Oliveira, Marinete Madalena de; UFPB. CCS. Departamento de Medicina. João Pessoa. BR
Rev. bras. ciênc. saúde ; 10(2): 143-150, maio-ago. 2006. ilus
Article in English, Portuguese | LILACS | ID: lil-469173
RESUMO

Objetivo:

Demonstrar que o uso de terapia anti-retroviral combinada é mais efetiva do que o uso do AZT em monoterapia (1a fase ACTG 076) durante o pré-natal de mulheres gestantes portadoras do HIV/AIDS. Material e

Métodos:

Estudo longitudinal, descritivo com abordagem quantitativa realizado no SAE Materno-Infantil do Hospital Universitário Lauro Wanderley da Universidade Federal da Paraíba - Brasil, no período de abril de 1997 a abril de 2005. Participaram 209 gestantes HIV+ ou com AIDS, matriculadas no Pré-Natal do referido serviço especializado e suas crianças expostas ao HIV.

Resultados:

Mostram uma taxa de transmissão do HIV de 0,9% de crianças infectadas cujas mães fizeram uso de AZT (Zidovudina) em monoterapia e de 100% de crianças não infectadas quando foi usada a Terapia Anti-Retroviral combinada com AZT+3TC+NFV (Zidovudina+Lamivudina+Nelfinavir).

Conclusão:

O uso de Terapia Anti-Retroviral Combinada reduz a carga viral materna reduzindo a taxa de transmissão vertical inferior a 1%, enquanto o AZT em monoterapia não reduz suficientemente a carga viral materna elevanda a taxa de transmissão do HIV < ou = 2%, à criança.
ABSTRACT

Objective:

To demonstrate that the use of combined antiretroviral therapy is more effective than the use of AZT in monotherapy (1st. phase ACTG 076) during prenatal period of pregnant women affected by HIV/AIDS. Material and

Methods:

Longitudinal, descriptive and quantitatively approached study carried out at SAE Materno-Infantil from Hospital Universitário Lauro Wanderley at Universidade Federal da Paraíba - Brazil, in the period of April 1997 to April 2005. There were 209 pregnant women who were HIV+ or had AIDS as part of this study, enrolled in the prenatal assistance of the referred specialized service and their babies, who were exposed to HIV.

Results:

There was an HIV transmission rate of 0,9% of infected babies whose mothers made use of AZT (Zidovudine) in monotherapy and of 100% of non-infected babies when the antiviretroviral therapy combined with AZT+3TC+NFV (Zidovudine+Lamivudine+Nelfinavir) was used.

Conclusion:

The use of combined antiretroviral therapy reduces the maternal viral load, consequently reducing the vertical transmission rate to below 1%, while AZT in monotherapy does not significantly reduce the maternal viral load, raising the transmission rate of HIV < or = 2%, for the baby.
Subject(s)
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Index: LILACS (Americas) Main subject: Prenatal Care / HIV / Combined Modality Therapy / Infectious Disease Transmission, Vertical / Pregnant Women / Anti-Retroviral Agents Type of study: Observational study Limits: Female / Humans / Pregnancy Language: English / Portuguese Journal: Rev. bras. ciênc. saúde Journal subject: Medicine Year: 2006 Type: Article Affiliation country: Brazil Institution/Affiliation country: UFPB/BR

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Index: LILACS (Americas) Main subject: Prenatal Care / HIV / Combined Modality Therapy / Infectious Disease Transmission, Vertical / Pregnant Women / Anti-Retroviral Agents Type of study: Observational study Limits: Female / Humans / Pregnancy Language: English / Portuguese Journal: Rev. bras. ciênc. saúde Journal subject: Medicine Year: 2006 Type: Article Affiliation country: Brazil Institution/Affiliation country: UFPB/BR