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Interleukin-11 attenuates ifosfamide-induced hemorrhagic cystitis
Mota, Jose M; Brito, Gerly A; Loiola, Raphael T; Cunha, Fernando Q; Ribeiro, Ronaldo de A.
  • Mota, Jose M; Federal University of Ceara. School of Medicine. Departments of Physiology and Pharmacology and Morphology. Ribeirao Preto. BR
  • Brito, Gerly A; Federal University of Ceara. School of Medicine. Departments of Morphology. Ribeirao Preto. BR
  • Loiola, Raphael T; Federal University of Ceara. School of Medicine. Departments of Physiology and Pharmacology and Morphology. Ribeirao Preto. BR
  • Cunha, Fernando Q; University of Sao Paulo Ribeirao Preto. School of Medicine. Department of Pharmacology. Ribeirao Preto. BR
  • Ribeiro, Ronaldo de A; Federal University of Ceara. School of Medicine. Departments of Physiology and Pharmacology and Morphology. Ribeirao Preto. BR
Int. braz. j. urol ; 33(5): 704-710, Sept.-Oct. 2007. ilus, graf, tab
Article in English | LILACS | ID: lil-470222
ABSTRACT

OBJECTIVE:

To investigate the possible protective effect of recombinant human interleukin-11 (rhIL-11) against ifosfamide (IFS)-induced hemorrhagic cystitis (HC) MATERIALS AND

METHODS:

Male Swiss mice (20-30g) were pretreated with rhIL-11 (25-625 mg, subcutaneously.) 30 min before intraperitoneal injection of IFS (400 mg/kg) or with saline (control group). Twelve hours later, HC was evaluated by bladder wet weight (BWW) to quantify edema, Evans blue extravasation (EBE) to measure vascular permeability, and macroscopic and microscopic analysis. All bladders were assessed by histopathological analysis

RESULTS:

rhIL-11 (at 125 and 625 mg) attenuated the IFS- induced increase of BWW (37.48 percent and 45.44 percent, respectively, p < 0.05) and EBE (62.35 percent and 56.47 percent, respectively, p < 0.05). IFS- induced macroscopic edema and hemorrhage and microscopic alterations, were also prevented by rhIL-11 at 625 mg. (p < 0.05)

CONCLUSION:

Our results demonstrate a protective effect of rhIL-11 on experimental IFS- induced HC, not previously reported.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Antineoplastic Agents, Alkylating / Cystitis / Hemorrhage / Ifosfamide Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2007 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Ceara/BR / University of Sao Paulo Ribeirao Preto/BR

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Full text: Available Index: LILACS (Americas) Main subject: Antineoplastic Agents, Alkylating / Cystitis / Hemorrhage / Ifosfamide Limits: Animals Language: English Journal: Int. braz. j. urol Journal subject: Urology Year: 2007 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Ceara/BR / University of Sao Paulo Ribeirao Preto/BR