Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
Mem. Inst. Oswaldo Cruz
;
102(7): 883-885, Nov. 2007. ilus, graf
Article
in English
| LILACS
| ID: lil-470353
ABSTRACT
The relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerized morphometric measurements of fibrosis, and the counting of blood vessels from hepatic schistosomal lesions did not significantly differ when treated animals and their controls were compared at the end of the experiments. These rather unexpected results are presented under the understanding that they may be of interest during further studies on the anti-angiogenesis properties of thalidomide, and the relationship between angiogenesis and fibrosis.
Full text:
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Index:
LILACS (Americas)
Main subject:
Thalidomide
/
Schistosomiasis mansoni
/
Angiogenesis Inhibitors
/
Liver
/
Liver Cirrhosis
/
Neovascularization, Pathologic
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2007
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fiocruz/BR
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