Non-random distribution of high density chromatin detected at opposite ends of T-banded human metaphase chromosomes
Genet. mol. biol
;
30(4): 1054-1057, 2007. ilus
Article
in English
| LILACS
| ID: lil-471027
ABSTRACT
Previous research using microdensitometric scanning and computer graphic image analysis showed that T-banded segments of human metaphase chromosomes usually exhibit an asymmetrical distribution of high density (HD) chromatin between sister chromatids. Here, we employed the same methods to analyze HD chromatin distribution at opposite ends of T-banded human lymphocyte chromosomes. This study revealed that in most chromosomes with an asymmetrical distribution of HD chromatin at both ends, the highest densities of each arm were located in opposite chromatids. The frequency of this configuration was 0.792 per chromosome, indicating that the highest chromatin densities of the terminal segments of T-banded human chromosomes were non-randomly distributed at opposite chromosome arms. The possible relationship of this observation to the mode of replication of the terminal chromosome region is briefly discussed.
Full text:
Available
Index:
LILACS (Americas)
Type of study:
Controlled clinical trial
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
2007
Type:
Article
Affiliation country:
Uruguay
Institution/Affiliation country:
Instituto de Investigaciones Biológicas Clemente Estable/UY
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