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Effect of low-dose electron radiation on rat skin wound healing
Almeida, Solange Maria de; Cruz, Adriana Dibo da; Ferreira, Rívea Inês; Vizioli, Mário Roberto; Bóscolo, Frab Norberto.
  • Almeida, Solange Maria de; State University of Campinas. School of Dentistry of Piracicaba. Department of Oral Diagnosis. Piracicaba. BR
  • Cruz, Adriana Dibo da; State University of Campinas. School of Dentistry of Piracicaba. Department of Oral Diagnosis. Piracicaba. BR
  • Ferreira, Rívea Inês; São Paulo City University. Department of Pediatric Dentistry and Orthodontics. São Paulo. BR
  • Vizioli, Mário Roberto; State University of Campinas. School of Dentistry of Piracicaba. Department of Oral Pathology. Piracicaba. BR
  • Bóscolo, Frab Norberto; State University of Campinas. School of Dentistry of Piracicaba. Department of Oral Diagnosis. Piracicaba. BR
Braz. dent. j ; 18(3): 208-214, 2007. ilus, tab
Article in English | LILACS | ID: lil-471442
ABSTRACT
The aim of this study was to assess the effect of low-dose electron irradiation on morphological features of the wound healing process in rat skin. Surgical wounds were inflicted with a 2.3 x 1.4 cm template on 84 male rats that were assigned to 4 groups IG1, immediately irradiated; IG2, irradiated 3 days after inflicting the wound; CG1 and CG2, control groups. Rats in IG1 and IG2 groups had their wounds exposed to 1 Gy of 6 MeV electron beam radiation, immediately after surgery and on the third postoperative day, respectively. Qualitative and histophotometric evaluations of tissue repair structures were carried out. Data were analyzed by ANOVA and Tukey's test (alpha = 0.05) and regression analysis. The repair process was delayed since the first sacrifice time in both irradiated groups, but in IG1, wound healing was closer to that of CG1; whereas in IG2, the delay was more pronounced. Based on the histological findings, it is possible to conclude that a low-dose of electron radiation delayed tissue repair in rat skin. The delay was longer in the skin irradiated 3 days after the beginning of tissue repair. However, the low-energy electron irradiation did not prevent wound healing.
RESUMO
O objetivo deste estudo foi avaliar o efeito da irradiação por baixa dose de elétrons sobre características morfológicas da reparação tecidual na pele de rato. Foram realizadas feridas cirúrgicas com um gabarito de 2,3 x 1,4 cm em 84 ratos machos, divididos em 4 grupos IG1, irradiado imediatamente; IG2, irradiado 3 dias após a produção da ferida; CG1 e CG2, grupos controles. Os ratos dos grupos IG1 e IG2 tiveram suas feridas expostas a 1 Gy de radiação por elétrons com 6 MeV, imediatamente após a cirurgia e ao terceiro dia pós-operatório, respectivamente. Procedeu-se às avaliações qualitativas e histofotométrica das estruturas de reparação tecidual. Os dados foram submetidos a ANOVA e teste Tukey (a = 0,05) e análise de regressão. O processo de reparação apresentou-se atrasado desde o primeiro tempo de sacrifício em ambos os grupos irradiados, mas para IG1, a reparação tecidual foi similar a CG1. Por outro lado, para IG2, o retardo foi mais pronunciado. Com base nas avaliações histológicas, é possível concluir que uma baixa dose de radiação por elétrons retardou a reparação na pele de rato. O atraso foi maior na pele irradiada 3 dias após o início da reparação tecidual. No entanto, esta irradiação por elétrons de baixa energia não impediu a cicatrização.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Skin / Wound Healing / Beta Particles / Glycosaminoglycans / Granulation Tissue Type of study: Qualitative research Limits: Animals Language: English Journal: Braz. dent. j Journal subject: Dentistry Year: 2007 Type: Article Affiliation country: Brazil Institution/Affiliation country: State University of Campinas/BR / São Paulo City University/BR

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Full text: Available Index: LILACS (Americas) Main subject: Skin / Wound Healing / Beta Particles / Glycosaminoglycans / Granulation Tissue Type of study: Qualitative research Limits: Animals Language: English Journal: Braz. dent. j Journal subject: Dentistry Year: 2007 Type: Article Affiliation country: Brazil Institution/Affiliation country: State University of Campinas/BR / São Paulo City University/BR