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Encefalopatía asociada a Valproato / Val proate-associated hyperammonemic encephalopathy. Report of one case
Young, Pablo; Finn, Bárbara C; Álvarez, Florencia; Bruetman, Julio E; Trimarchi, Hernán.
  • Young, Pablo; Hospital Británico de Buenos Aires. Servicios de Clínica Médica y Nefrología. Buenos Aires. AR
  • Finn, Bárbara C; Hospital Británico de Buenos Aires. Servicios de Clínica Médica y Nefrología. Buenos Aires. AR
  • Álvarez, Florencia; Hospital Británico de Buenos Aires. Servicios de Clínica Médica y Nefrología. Buenos Aires. AR
  • Bruetman, Julio E; Hospital Británico de Buenos Aires. Servicios de Clínica Médica y Nefrología. Buenos Aires. AR
  • Trimarchi, Hernán; Hospital Británico de Buenos Aires. Servicios de Clínica Médica y Nefrología. Buenos Aires. AR
Rev. méd. Chile ; 135(11): 1446-1449, nov. 2007. tab
Article in Spanish | LILACS | ID: lil-472844
ABSTRACT
Valproate can be associated to hyperammonemic encephalopathy, characterized by fluctuating sudden-onset alterations of sensorium, focal symptoms and an increase in the frequency of seizures. We report a 78 year-old female using valproate 1,000 mg/ day for 10 months for the treatment to tonic-clonic seizures. She was admitted on three occasions in the last fourth months for self limited clouding of sensorium. Laboratory, imaging and electroencephalografic studies were non-contributory Blood ammonia levels were 123 fig/dl (normal 15-50 fig/dl). Due to the possibility of a hyperammonemic encephalopathy secondary to valproate, the drug was discontinued and she was treated with lactulose and intravenous L-carnitine, 1 g/day The patient showed a complete recovery within 48 hours. This drug-associated encephalopathy is a reversible but potentially fatal cause, probably underdiagnosed, that requires a high index of suspicion.
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Full text: Available Index: LILACS (Americas) Main subject: Brain Diseases / Valproic Acid / Hyperammonemia / Anticonvulsants Type of study: Diagnostic study / Risk factors Limits: Aged / Female / Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2007 Type: Article Affiliation country: Argentina Institution/Affiliation country: Hospital Británico de Buenos Aires/AR

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Full text: Available Index: LILACS (Americas) Main subject: Brain Diseases / Valproic Acid / Hyperammonemia / Anticonvulsants Type of study: Diagnostic study / Risk factors Limits: Aged / Female / Humans Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2007 Type: Article Affiliation country: Argentina Institution/Affiliation country: Hospital Británico de Buenos Aires/AR