Neuroprotection by caffeine and pentoxifylline during experimental cerebral ischaemia
West Indian med. j
;
48(1): 23-25, Mar. 1999.
Article
in English
| LILACS
| ID: lil-473124
ABSTRACT
Cerebral ischaemia was induced in anaesthetized rats by occlusion of the ipsilateral common carotid and middle cerebral arteries. The response to ischaemia was assessed by the reduction of the amplitude of recorded somatosensory evoked potentials (SSEPs), and the rate of recovery of the SSEPs during reperfusion. Caffeine and pentoxifylline when applied at 70 mM to the cortex for 60 min prior to induction of ischaemia significantly reduced the ischaemia induced attenuation of the SSEPs and hastened recovery to control levels. In contrast, application of normal saline or of the drugs for 15 min did not reduce the effect of ischaemia on the SSEPs. These results suggest that caffeine and pentoxifylline have potential roles in the management of patients with cerebral ischaemia.
Search on Google
Index:
LILACS (Americas)
Main subject:
Pentoxifylline
/
Vasodilator Agents
/
Caffeine
/
Brain Ischemia
/
Neuroprotective Agents
/
Central Nervous System Stimulants
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
West Indian med. j
Journal subject:
Medicine
Year:
1999
Type:
Article
Affiliation country:
Trinidad and Tobago
Institution/Affiliation country:
University of the West Indies/TT
Similar
MEDLINE
...
LILACS
LIS