Antibiotic susceptibility of Neisseria gonorrhoeae in Trinidad and Tobago
West Indian med. j
;
46(4): 107-110, Dec. 1997.
Article
in English
| LILACS
| ID: lil-473438
ABSTRACT
Treatment failures with standard doses of penicillin have been observed in the Sexually Transmitted Diseases (STD) clinics in Trinidad and Tobago. In the absence of an ongoing surveillance system, the antimicrobial susceptibility of 518 Neisseria gonorrhoeae strains was determined in order to guide treatment. 39 (7.6) strains were resistant to penicillin, including 27 (5.2) positive for beta-lactamase; that is penicillinase-producing Neisseria gonorrhoeae (PPNG). 51 (10) strains were resistant to tetracycline, with 26 (5.0) of these exhibiting high levels of resistance compatible with tetracycline resistant Neisseria gonorrhoeae (TRNG). Six strains showed evidence of having both PPNG and TRNG plasmids, and five strains showed chromosomally-mediated resistance to both penicillin and tetracycline. The overall resistance rate to penicillin and tetracycline was 17.7. There was no resistance to spectinomycin, cefuroxime, ceftriaxone and norfloxacin. The resistance rates demonstrated in this study are sufficiently significant to preclude the use of penicillin and tetracycline in the STD clinics and to justify the use of newer antimicrobials. It is essential that resistance patterns be monitored by continued surveillance.
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Index:
LILACS (Americas)
Main subject:
Penicillin Resistance
/
Tetracycline Resistance
/
Neisseria gonorrhoeae
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
English Caribbean
/
Trinidad and Tobago
Language:
English
Journal:
West Indian med. j
Journal subject:
Medicine
Year:
1997
Type:
Article
Affiliation country:
Trinidad and Tobago
Institution/Affiliation country:
University of the West Indies/TT
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