Myeloproliferative syndrome of monosomy 7: a brief report
Genet. mol. biol
;
31(1): 36-38, 2008.
Article
in English
| LILACS
| ID: lil-476147
ABSTRACT
We report the case of a five-month-old black male infant who had recurrent episodes of respiratory infections and also presented anemia and enlargements of the spleen, liver and lymphnodes. Hematological analysis revealed morphological abnormalities with megaloblastic dyserythropoiesis, while fetal hemoglobin assaying showed normal levels. Conventional and molecular cytogenetic analysis revealed monosomy of chromosome 7. Despite all therapeutic efforts during allogenic bone marrow transplantation, the child died due to generalized infection. The clinical and genetic distinctions between monosomy 7 syndrome and myelodysplastic disorders in childhood are discussed.
Full text:
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Index:
LILACS (Americas)
Main subject:
Myelodysplastic Syndromes
/
Monosomy
/
Myeloproliferative Disorders
Limits:
Humans
/
Infant
/
Male
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
2008
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto Nacional do Câncer/BR
/
Universidade Federal de Pernambuco/BR
/
Universidade de Pernambuco/BR
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