Your browser doesn't support javascript.
loading
Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
Souza, Claudio Lima; Barbosa, Cynara Gomes; Moura Neto, José Pereira de; Barreto, José Henrique; Reis, Mitermayer Galvão; Gonçalves, Marilda Souza.
  • Souza, Claudio Lima; Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
  • Barbosa, Cynara Gomes; Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
  • Moura Neto, José Pereira de; Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
  • Barreto, José Henrique; Clínica Onco. Salvador. BR
  • Reis, Mitermayer Galvão; Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
  • Gonçalves, Marilda Souza; Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador. BR
Genet. mol. biol ; 31(1): 39-41, 2008. tab
Article in English | LILACS | ID: lil-476148
ABSTRACT
The null genotype for glutathione S-transferase (GST, EC 2.5.1.18) gene polymorphisms is considered a risk factor for leukemia in different populations. In this work we investigated the GSTT1 and GSTM1 polymorphisms using multiplex PCR in 53 patients with chronic myeloid leukemia (CML), 23 with acute promyelocytic leukemia (APL) and 304 apparently healthy controls. In this association study we found that the GSTT1null genotype was more frequent in our group of APL patients than in the control group [OR = 2.75 (95 percent CI = 1.10-6.88)], providing evidence that a deletion in the GSTT1 gene could be a risk factor for this type of leukemia.
Subject(s)

Fulltext
Print
XML
Search on Google
Full text: Available Index: LILACS (Americas) Main subject: Leukemia, Promyelocytic, Acute / Leukemia, Myeloid / Glutathione Transferase Type of study: Etiology study Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2008 Type: Article Affiliation country: Brazil Institution/Affiliation country: Clínica Onco/BR / Fundação Oswaldo Cruz/BR

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
Search on Google
Full text: Available Index: LILACS (Americas) Main subject: Leukemia, Promyelocytic, Acute / Leukemia, Myeloid / Glutathione Transferase Type of study: Etiology study Limits: Adolescent / Adult / Female / Humans / Male Country/Region as subject: South America / Brazil Language: English Journal: Genet. mol. biol Journal subject: Genetics Year: 2008 Type: Article Affiliation country: Brazil Institution/Affiliation country: Clínica Onco/BR / Fundação Oswaldo Cruz/BR