Inducción de apoptosis por el principio activo citotóxico de Espeletia killipii Cuatr. sobre líneas celulares humanas / Induction of apoptosis by the citotoxic active principle of Espeletia killipii Cuatr. on human cell lines
Rev. bras. farmacogn
;
17(4): 497-500, out.-dez. 2007. graf, ilus
Article
in Spanish
| LILACS
| ID: lil-476195
RESUMO
O acetato de longipilina, o princípio ativo citotóxico, isolado de Espeletia killipii Cuatr., uma planta endêmica de Colômbia, é uma sesquiterpenlactona que tem a propriedade de induzir apoptose em algumas linhagens celulares de câncer de mama como MCF-7 e CSC-1595 (obtidas do Instituto Nacional de Cancerologia, Bogotá - Colômbia). Reconhecimento morfológico, método de Tunel e citometria de fluxo foram utilizados para avaliar a atividade apoptótica. Os resultados mostraram que a longipilina é um potencial agente antitumoral.
ABSTRACT
Longipilin acetate is the compound exhibiting cytotoxicity, isolated from endemic plant specie from Colombia, South America, Espeletia killipii Cuatr. Longipilin acetate is a sesquiterpenelactone having the ability to induce apoptosis in several breast cancer cell-lines like MCF-7 y CSC-1595 (obtained from National Cancer Institute, Bogotá Colombia), Morphological examination, nuclear DNA fragmentation, tunel and flow cytometry were used to evaluate apoptosis. Therefore longipilin acetate is a compound showing potential as an antitumor agent.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Biological Products
/
In Vitro Techniques
/
Apoptosis
/
Asteraceae
Language:
Spanish
Journal:
Rev. bras. farmacogn
Journal subject:
Pharmacy
Year:
2007
Type:
Article
Affiliation country:
Colombia
Institution/Affiliation country:
Fundación Universitaria San Martín/CO
/
Pontificia Universidad Javeriana/CO
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