Comparison between E-test and CLSI broth microdilution method for antifungal susceptibility testing of Candida albicans oral isolates / Comparação entre E-test e o método da microdiluição do CLSI para teste de susceptibilidade a antifúngicos de isolados orais de Candida albicans
Rev. Inst. Med. Trop. Säo Paulo
; Rev. Inst. Med. Trop. Säo Paulo;50(1): 7-10, Jan.-Feb. 2008. tab
Article
in En
| LILACS
| ID: lil-476755
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ABSTRACT
Thirty Candida albicans isolated from oral candidosis patients and 30 C. albicans isolated from control individuals were studied. In vitro susceptibility tests were performed for amphotericin B, fluconazole, 5-flucytosine and itraconazole through the Clinical and Laboratorial Standards Institute (CLSI) reference method and E test system. The results obtained were analyzed and compared. MIC values were similar for the strains isolated from oral candidosis patients and control individuals. The agreement rate for the two methods was 66.67 percent for amphotericin B, 53.33 percent for fluconazole, 65 percent for flucytosine and 45 percent for itraconazole. According to our data, E test method could be an alternative to trial routine susceptibility testing due to its simplicity. However, it can not be considered a substitute for the CLSI reference method.
RESUMO
Trinta Candida albicans isoladas de pacientes portadores de candidose oral e 30 Candida albicans isoladas de indivíduos controle foram estudadas. Testes de susceptibilidade in vitro foram realizados com anfotericina B, fluconazol, 5-flucitosina e itraconazol pelo método do Clinical and Laboratorial Standars Institute (CLSI) e por E-test. Os resultados obtidos foram analisados e comparados. Os valores de CIM foram semelhantes para amostras isoladas de pacientes portadores de candidose oral e indivíduos controle. A concordância entre os dois métodos foi de 66,7 por cento para a anfotericina B, 53,33 por cento para o fluconazol, 65 por cento para a flucitosina e 45 por cento para o itraconazol. De acordo com estes resultados, o método do E-test poderia ser uma alternativa para a triagem de casos de rotina pela sua simplicidade. Entretanto, este método não pode ser considerado como um substituto para o método de referência do CLSI.
Key words
Full text:
1
Index:
LILACS
Main subject:
Candida albicans
/
Antifungal Agents
Type of study:
Guideline
/
Observational_studies
Limits:
Humans
Language:
En
Journal:
Journal of the São Paulo Institute of Tropical Medicine
/
Rev Inst Med Trop Sao Paulo
/
Rev. Inst. Med. Trop. São Paulo (Online)
/
Rev. Inst. Med. Trop. Säo Paulo
/
Revista do Instituto de Medicina Tropical de Säo Paulo (Impresso)
Journal subject:
MEDICINA TROPICAL
Year:
2008
Type:
Article