Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
J. venom. anim. toxins incl. trop. dis
;
14(1): 82-99, 2008. ilus, graf
Article
in English
| LILACS
| ID: lil-479341
ABSTRACT
The present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each Group I - only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III - venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological evaluation. There was myonecrosis in the inoculated limb, renal tubular degeneration, lymphoid hyperplasia of spleen, and unspecific reactive hepatitis. These results show the antigenicity and action of the venom on the immune system.
Full text:
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Index:
LILACS (Americas)
Main subject:
Crotalid Venoms
/
Dogs
Limits:
Animals
Language:
English
Journal:
J. venom. anim. toxins incl. trop. dis
Journal subject:
Toxicology
Year:
2008
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Maringá University Center/BR
/
São Paulo State University/BR
/
University of Western São Paulo/BR
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