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Demyelinating disease in patients with myasthenia gravis
Bichuetti, Denis Bernardi; Barros, Tatiane Martins de; Oliveira, Enedina Maria Lobato; Annes, Marcelo; Gabbai, Alberto Alain.
  • Bichuetti, Denis Bernardi; Federal University of São Paulo. Neurology and Neurosurgery Department. São Paulo. BR
  • Barros, Tatiane Martins de; Federal University of São Paulo. Neurology and Neurosurgery Department. São Paulo. BR
  • Oliveira, Enedina Maria Lobato; Federal University of São Paulo. Neurology and Neurosurgery Department. São Paulo. BR
  • Annes, Marcelo; Federal University of São Paulo. Neurology and Neurosurgery Department. São Paulo. BR
  • Gabbai, Alberto Alain; Federal University of São Paulo. Neurology and Neurosurgery Department. São Paulo. BR
Arq. neuropsiquiatr ; 66(1): 5-7, mar. 2008. ilus, tab
Article in English | LILACS | ID: lil-479639
ABSTRACT
Myasthenia gravis (MG) is an autoimmune disease characterized by fluctuating muscle weakness, caused by impaired neuromuscular transmission. Patients with MG can present other autoimmune diseases in association, commonly hypo or hyperthyroidism. The association of MG to demyelinating disease is rare and has been described before. We report on three Brazilian patients with MG that presented distinct demyelinating diseases, two monophasic and one recurrent neuromyelitis optica, several years after the diagnosis of MG, and discuss their clinical courses.
RESUMO
Miastenia gravis (MG) é doença autoimune caracterizada por episódios de fraqueza muscular alternados com melhora, causada por bloqueio da junção neuromuscular. Pacientes com MG podem apresentar outras doenças autoimunes, comumente hipo ou hipertiroidismo, e a associação de MG com doenças desmielinizantes é raramente descrita. Relatamos três pacientes brasileiros com MG que desenvolveram doenças desmielinizantes, dois monofásicos e um neuromielite óptica recorrente, vários anos após o diagnóstico de MG e discutimos seus cursos clínicos.
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Full text: Available Index: LILACS (Americas) Main subject: Demyelinating Diseases / Myasthenia Gravis Type of study: Diagnostic study / Etiology study Limits: Adult / Female / Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2008 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of São Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Demyelinating Diseases / Myasthenia Gravis Type of study: Diagnostic study / Etiology study Limits: Adult / Female / Humans / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2008 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of São Paulo/BR