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Comparison of the biocompatibility of different root canal irrigants
Gomes-Filho, João Eduardo; Aurélio, Kamila Guilherme; Costa, Mariana Machado Teixeira de Moraes; Bernabé, Pedro Felício Estrada.
  • Gomes-Filho, João Eduardo; São Paulo State University. Dental School of Araçatuba. Department of Restorative Dentistry. Araçatuba. BR
  • Aurélio, Kamila Guilherme; São Paulo State University. Dental School of Araçatuba. Department of Restorative Dentistry. Araçatuba. BR
  • Costa, Mariana Machado Teixeira de Moraes; São Paulo State University. Dental School of Araçatuba. Department of Restorative Dentistry. Araçatuba. BR
  • Bernabé, Pedro Felício Estrada; São Paulo State University. Dental School of Araçatuba. Department of Restorative Dentistry. Araçatuba. BR
J. appl. oral sci ; 16(2): 137-144, Mar.-Apr. 2008. ilus
Article in English | LILACS | ID: lil-479760
ABSTRACT
The purpose of this study was to compare the reaction of rat subcutaneous connective tissue to 0.9 percent sterile saline, 2.5 percent sodium hypochlorite (NaOCl), 5.25 percent NaOCl and 2 percent chlorhexidine gluconate solution or gel. Six circles were demarcated on the dorsal skin of 24 male Wistar rats, leaving 2 cm between each circle. Using a syringe, 0.1 mL of each root canal irrigant was injected subcutaneously into 5 circles. In the 6th circle, the needle of an empty syringe was introduced into the skin, but no irrigant was injected (control group). Evaluations were undertaken at 2 h, 48 h, 14 days and 30 days post-procedure. Tissue samples were excised, embedded in paraffin blocks and 3-µm-thick sections were obtained and stained with hematoxylin and eosin. The areas of inflammatory reaction were evaluated and analyzed statistically by ANOVA and Tukey's test. The control group showed few or no inflammatory reaction areas in the subcutaneous tissue. 0.9 percent saline solution, 2.0 percent chlorhexidine solution and 2.5 percent NaOCl showed a good biocompatibility, as very mild inflammatory reaction was detected at 14 days and tissue repair occurred at 30 days. 5.25 percent NaOCl was the most toxic irrigant, as the number of inflammatory cells remained elevated at 14 and 30 days. The group treated with 2.0 percent chlorhexidine gluconate gel presented a moderate inflammatory response at 14 days, which decreased at 30 days, being considered similar to that of the control group, 0.9 percent saline solution, 2.0 percent chlorhexidine solution and 2.5 percent NaOCl at this experimental period.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Root Canal Irrigants / Biocompatible Materials Limits: Animals Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2008 Type: Article Affiliation country: Brazil Institution/Affiliation country: São Paulo State University/BR

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Full text: Available Index: LILACS (Americas) Main subject: Root Canal Irrigants / Biocompatible Materials Limits: Animals Language: English Journal: J. appl. oral sci Journal subject: Dentistry Year: 2008 Type: Article Affiliation country: Brazil Institution/Affiliation country: São Paulo State University/BR