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High frequency of p 16 promoter methylation in non-small cell lung carcinomas from Chile
Guzman, Leda M; Koriyama, Chihaya; Akiba, Suminori; Eizuru, Yoshito; Castillo, Darwins; Corvalan, Alejandro; Aguayo, Francisco R.
  • Guzman, Leda M; Universidad Santo Tomás. Facultad de Salud. Escuela de Tecnología Médica. CL
  • Koriyama, Chihaya; Kagoshima University Graduate School of Medical and Dental Sciences. Department of Epidemiology and Preventive Medicine. Kagoshima. JP
  • Akiba, Suminori; Kagoshima University Graduate School of Medical and Dental Sciences. Department of Epidemiology and Preventive Medicine. Kagoshima. JP
  • Eizuru, Yoshito; Kagoshima University Graduate School of Medical and Dental Sciences. Center for Chronic Viral Diseases. Division of Oncogenic and Persistent Viruses. Kagoshima. JP
  • Castillo, Darwins; Instituto de Salud Pública de Chile. Laboratorio Nacional y de Referencia de Inmunología. Santiago. CL
  • Corvalan, Alejandro; Instituto de Salud Pública de Chile. Laboratorio Nacional y de Referencia de Inmunología. Santiago. CL
  • Aguayo, Francisco R; Kagoshima University Graduate School of Medical and Dental Sciences. Center for Chronic Viral Diseases. Division of Oncogenic and Persistent Viruses. Kagoshima. JP
Biol. Res ; 40(3): 365-372, 2007. ilus, tab
Article in English | LILACS | ID: lil-481314
ABSTRACT
The inactivation of tumour suppressor genes by aberrant methylation of promoter regions has been described as a frequent event in neoplasia development, including lung cancer. The p16 gene is a tumour suppressor gene involved in the regulation of cell cycle progression that has been reported to be inactivated by promoter methylation in lung carcinomas at variable frequencies around the world in a smoking habit dependent manner. The purpose of this study was to investigate the methylation status of the promoter region of the p16 gene in 74 non-small cell lung carcinomas from Chile. The frequency of p16 gene inactivation by promoter methylation was determined as 79.7 percent (59/74). When we considered histological type, we observed that p16 promoter methylation was significantly higher in squamous cell carcinomas (30/33, 91 percent) compared with adenocarcinomas (21/30, 70 percent) (p=0.029). In addition, no association between p16 promoter methylation and gender, age or smoking habit was found (p=0.202, 0.202 and 0.147 respectively). Our results suggest that p16 promoter hypermethylation is a very frequent event in non-small cell lung carcinomas from Chile and could be smoking habit-independent.
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Full text: Available Index: LILACS (Americas) Main subject: Smoking / Promoter Regions, Genetic / Carcinoma, Non-Small-Cell Lung / DNA Methylation / Lung Neoplasms Type of study: Etiology study Limits: Aged / Female / Humans / Male Country/Region as subject: South America / Chile Language: English Journal: Biol. Res Journal subject: Biology Year: 2007 Type: Article / Project document Affiliation country: Chile / Japan Institution/Affiliation country: Instituto de Salud Pública de Chile/CL / Kagoshima University Graduate School of Medical and Dental Sciences/JP / Universidad Santo Tomás/CL

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Full text: Available Index: LILACS (Americas) Main subject: Smoking / Promoter Regions, Genetic / Carcinoma, Non-Small-Cell Lung / DNA Methylation / Lung Neoplasms Type of study: Etiology study Limits: Aged / Female / Humans / Male Country/Region as subject: South America / Chile Language: English Journal: Biol. Res Journal subject: Biology Year: 2007 Type: Article / Project document Affiliation country: Chile / Japan Institution/Affiliation country: Instituto de Salud Pública de Chile/CL / Kagoshima University Graduate School of Medical and Dental Sciences/JP / Universidad Santo Tomás/CL