Frequency of Colorectal Cancer and Extracolonic Tumors in Families That Meet Amsterdam Criteria I and II: Results From Hospital A. C. Camargo Hereditary Colorectal Cancer Registry
Appl. cancer res
;
27(1): 18-22, Jan.-Mar. 2007.
Article
in English
| LILACS, Inca
| ID: lil-481541
ABSTRACT
An estimated 1% to 10% of all colorectal tumors (CRC) are related to high-penetrance genes. Families with Lynch Syndrome, caused by mutations in MMR repair genes, present a high frequency, not only of CRC, but also extracolonic tumors. Objective:
To verify the frequency of CRC and extracolonic cancers in families that meet Amsterdam I and II criteria.Methods:
Families had been included that meet Amsterdam I and II criteria, in the Registry of Colorectal Cancer of A. C. Camargo Hospital from 1992 to 2007. Family history was taken and stored in the Cyrillic® 2.1 software. Data collection forms were filled.Results:
1578 individuals were identified, and 337 of them presented tumors. CRC was the most frequent, with 221 individuals,with a mean age of 46 years at diagnosis. The most frequent extracolonic tumors were breast (17 cases), endometrium (15), stomach (14), urinary (12), leukemia (9), and prostate (6).Discussion:
As expected, the age at diagnosis of colorectalcancer was younger than the general population; breast tumor was the most frequent; molecular studies must differentiate patients with Lynch Syndrome (LS) from those with familial colorectal cancer.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Colorectal Neoplasms
/
Colorectal Neoplasms, Hereditary Nonpolyposis
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Appl. cancer res
Journal subject:
Neoplasms
Year:
2007
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Faculdade de Medicina de Jundiaí/BR
/
Hospital A. C. Camargo/BR
/
Universidade Estadual de Londrina/BR
Similar
MEDLINE
...
LILACS
LIS