Valor pronóstico del nuevo sistema de etapificación internacional en mieloma múltiple: Comparación con el sistema de Durie-Salmon / Prognostic value of the new international staging system in multiple myeloma: Comparison with Durie-Salmon staging system
Rev. méd. Chile
;
136(1): 7-12, ene. 2008. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-483214
ABSTRACT
Background:
Since 1975, the Durie-Salmon staging system (D&S) has been a widely accepted prognostic classification of multiple myeloma (MM) patients. Recently, the new International Staging System (ISS) was developed using only the values of albumin and betaZ-microglobulin.Aim:
To compare survival of patients with MM treated in six medical centers in Chile according to the D&S system and the new ISS. Material andmethods:
Retrospective analysis of demographic information, clinical features and survival rate of patients treated between 1998 and 2002, and grouped according to both systems.Results:
Information of 81 patients aged 38 to 90 years (43 women) was retrieved. According D&S system 11 percent were in stage I 12 percent in stage II and 73 percent in stage III According to ISS, 34 percent were in stage I 35 percent in stage II and 31 percent in stage III Median of survival of all patients was 32 months. Both staging systems had a prognostic value. However, median survival for the three stages of the ISS system was significantly different (67, 29 and 14 months in stages III and III, respectively, p =0.02). Patients in advanced stages II and III of the ISS, had a higher frequency of anemia, hypercalcemia, renal failure and hypoalbuminemia. In stages II and III of ISS the presence of renal failure was associated with a non significantly different lower survival.Conclusions:
The ISS is a simple and effective grouping method for patients with MM, that predicts survival. The presence of renal insufficiency might identify a subgroup of patients included in stages II and III of ISS with a higher mortality.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Multiple Myeloma
/
Neoplasm Staging
Type of study:
Controlled clinical trial
/
Prognostic study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Chile
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2008
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Barros Luco T/CL
/
Hospital Salvador/CL
/
Hospital San Borja A/CL
/
Hospital Sótero del Río/CL
/
Universidad Austral de Chile/CL
/
Universidad de Chile/CL
Similar
MEDLINE
...
LILACS
LIS