Objetivos moleculares para diseñar nuevos fármacos para el tratamiento de la diabetes tipo 2 y la obesidad: [revisión] / Molecular targets for new drug discovery to treat type 2 diabetes and obesity: [review]
Rev. méd. Chile
;
136(1): 107-117, ene. 2008. ilus
Article
in Spanish
| LILACS
| ID: lil-483227
ABSTRACT
Current strategies to treat type 2 diabetes (DMT2) include reducing insulin resistance using glitazones, supplementing with exogenous insulin, increasing endogenous insulin production with sulfonylureas and meglitinides, reducing hepatic glucose production through biguanides, and limiting postprandial glucose absorption with alpha-glucosidase inhibitors. In all of these areas, new generations of molecules with improved efficacy and safety profiles, are being investigated. Promising biological targets are rapidly emerging such as the role of lipotoxicity as a cause of glucometabolic insulin resistance, leading to a host of new molecular drug targets such as AMP-activated protein kinase (AMPK) activators, recombinant adiponectin derivatives, and fatty acid synthase (FAS) inhibitors. Insulin action can be enhanced in muscle, liver and fat, with small-molecule activators of the insulin receptor or inhibitors of protein tyrosine phosphatase (FTP)-IB. Defective glucose-stimulated insulin secretion by pancreatic B-cells could be alleviated with recombinant glucagon-like peptide (GLP-1) or agonists to the GLP-1 receptor. This review presents a new approach for obesity and DMT2 drug discovery through pharmacogenomics. Several compounds have already been validated through genetic engineering in animal models or the preliminary use of therapeutic compounds in humans.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Drug Design
/
Anti-Obesity Agents
/
Hypoglycemic Agents
/
Obesity
Limits:
Animals
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2008
Type:
Article
Affiliation country:
Argentina
/
Chile
/
Mexico
/
United States
Institution/Affiliation country:
Instituto Mexicano del Seguro Social/MX
/
Secretaría de Salud Pública/MX
/
Sociedad Argentina de Obesidad y Trastornos Alimentarios/AR
/
Southwest Foundation for Biomedical Research/US
/
Universidad Mayor/CL
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