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Anatomopathological study in BALB/c mice brains experimentally infected with Toxoplasma gondii
Silva, Marcos Gontijo da; Lino Junior, Ruy de Souza; Costa, Tatiane Luiza da; Soares, Joanna D´arc Herzog; Amaral, Waldemar Naves do; Avelino, Mariza Martins; Castro, Ana Maria de.
  • Silva, Marcos Gontijo da; Federal University of Goias. Postgraduate program from the Tropical Pathology and Public Health Institute. Goiânia. BR
  • Lino Junior, Ruy de Souza; UFG. IPTSP. Immunology, Parasitology and Pathology Department. General Pathology Sector from Microbiology. Goiânia. BR
  • Costa, Tatiane Luiza da; Federal University of Goias. Postgraduate program from the Tropical Pathology and Public Health Institute. Goiânia. BR
  • Soares, Joanna D´arc Herzog; UFG. IPTSP. DMIPP. Parasitology Sector. Goiânia. BR
  • Amaral, Waldemar Naves do; UFG. Medicine School. Gynecology and Obstetrics Department. Goiânia. BR
  • Avelino, Mariza Martins; UFG. Medicine School. Pediatrics and Puericulture Department. Goiânia. BR
  • Castro, Ana Maria de; UFG. IPTSP. DMIPP. Parasitology Sector. Goiânia. BR
Braz. j. infect. dis ; 12(1): 52-56, Feb. 2008. ilus, tab
Article in English | LILACS | ID: lil-484419
ABSTRACT
Toxoplasmosis is one of the most important diseases of the nervous central system, leading to severe symptoms and, many times, irreversible sequelae. This work demonstrated the main anatomopathological lesions caused by Toxoplasma gondii in brains from experimentally infected BALB/c mice. We analyzed 51 cases of mice that developed toxoplasmosis after experimental infection by intraperitoneal inoculation of blood, amniotic liquid and cerebrospinal fluid from fetuses, newly born children and pregnant women with clinical and laboratory signals of toxoplasmosis. In all experiments where we detected the parasite in mice we also detected pathological lesions in the animal brains with great polymorphism between experiments. Edema was the most found lesion in all cases. Besides, it was possible to demonstrate the inflammatory process in 82.4 percent of cases and necrosis in 64.7 percent of cases, in agreement with the literature that describes severe neurological damage in its hosts.
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Full text: Available Index: LILACS (Americas) Main subject: Brain / Toxoplasmosis, Animal / Central Nervous System Protozoal Infections Limits: Animals / Female / Humans / Pregnancy Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2008 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Goias/BR / UFG/BR

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Full text: Available Index: LILACS (Americas) Main subject: Brain / Toxoplasmosis, Animal / Central Nervous System Protozoal Infections Limits: Animals / Female / Humans / Pregnancy Language: English Journal: Braz. j. infect. dis Journal subject: Communicable Diseases Year: 2008 Type: Article Affiliation country: Brazil Institution/Affiliation country: Federal University of Goias/BR / UFG/BR