Anatomopathological study in BALB/c mice brains experimentally infected with Toxoplasma gondii
Braz. j. infect. dis
;
12(1): 52-56, Feb. 2008. ilus, tab
Article
in English
| LILACS
| ID: lil-484419
ABSTRACT
Toxoplasmosis is one of the most important diseases of the nervous central system, leading to severe symptoms and, many times, irreversible sequelae. This work demonstrated the main anatomopathological lesions caused by Toxoplasma gondii in brains from experimentally infected BALB/c mice. We analyzed 51 cases of mice that developed toxoplasmosis after experimental infection by intraperitoneal inoculation of blood, amniotic liquid and cerebrospinal fluid from fetuses, newly born children and pregnant women with clinical and laboratory signals of toxoplasmosis. In all experiments where we detected the parasite in mice we also detected pathological lesions in the animal brains with great polymorphism between experiments. Edema was the most found lesion in all cases. Besides, it was possible to demonstrate the inflammatory process in 82.4 percent of cases and necrosis in 64.7 percent of cases, in agreement with the literature that describes severe neurological damage in its hosts.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Brain
/
Toxoplasmosis, Animal
/
Central Nervous System Protozoal Infections
Limits:
Animals
/
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
2008
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Goias/BR
/
UFG/BR
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