Presencia de metalo-ß-lactamasas en Pseudomonas aeruginosa resistente a imipenem / Presence of metal lo ß-lactamases in imipenem-resistant Pseudomonas aeruginosa
Rev. méd. Chile
;
136(4): 423-432, abr. 2008. ilus, tab, graf
Article
in Spanish
| LILACS
| ID: lil-484917
ABSTRACT
Background:
Metallo-ß-lactamases (MBL) confer high resistance to carbapenems in Pseudomonas aeruginosa (Psae). They are encoded in mobile elements of different genes (VIM, IMP, SMP, GIM), along with other resistance genes.Aim:
To detect the presence of MBL in imipenem resistant Psae strains. Material andmethods:
Fifty-nine imipenem resistant Psae strains isolated from January 2004 to August 2005 in a University Clinical Hospital, were included. The presence of MBL was studied by Etest (phenotypic) and genotypic polymerase chain reaction (PCR) methods. To rule out a nosocomial outbreak, MBL positive strains, were studied by pulse field gel electrophoresis.Results:
The presente of MBL was detected in eleven strains. AH were type VIM and were not clonally related. There was no concordance between phenotypic and genotypic MBL detecting methods. AH the strains were also multiresistant.Conclusions:
The presence of MBL was detected in 19 percent of imipenem resistant Psae strains.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pseudomonas aeruginosa
/
Pseudomonas Infections
/
Beta-Lactamases
/
Imipenem
/
Anti-Bacterial Agents
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2008
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Hospital Militar/CL
/
Pontificia Universidad Católica de Chile/CL
/
Universidad de Concepción/CL
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