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Polysaccharide-rich fraction of Agaricus brasiliensis enhances the candidacidal activity of murine macrophages
Martins, Priscila Raquel; Gameiro, Maria Carolina; Castoldi, Lindsey; Romagnoli, Graziela Gorete; Lopes, Fabiane Catanho; Pinto, Andréa Vanessa Ferreira da Silva; Loyola, Wagner; Kaneno, Ramon.
  • Martins, Priscila Raquel; Universidade Estadual Paulista. Instituto de Biociências. Departamento de Microbiologia e Imunologia. Botucatu. BR
  • Gameiro, Maria Carolina; Universidade Estadual Paulista. Instituto de Biociências. Departamento de Microbiologia e Imunologia. Botucatu. BR
  • Castoldi, Lindsey; Universidade Estadual Paulista. Instituto de Biociências. Departamento de Microbiologia e Imunologia. Botucatu. BR
  • Romagnoli, Graziela Gorete; Universidade Estadual Paulista. Instituto de Biociências. Departamento de Microbiologia e Imunologia. Botucatu. BR
  • Lopes, Fabiane Catanho; Universidade Estadual Paulista. Instituto de Biociências. Departamento de Microbiologia e Imunologia. Botucatu. BR
  • Pinto, Andréa Vanessa Ferreira da Silva; Universidade Estadual Paulista. Instituto de Biociências. Departamento de Microbiologia e Imunologia. Botucatu. BR
  • Loyola, Wagner; Universidade Bandeirantes. Bandeirantes. BR
  • Kaneno, Ramon; Universidade Estadual Paulista. Instituto de Biociências. Departamento de Microbiologia e Imunologia. Botucatu. BR
Mem. Inst. Oswaldo Cruz ; 103(3): 244-250, May 2008. ilus, graf
Article in English | LILACS | ID: lil-485211
ABSTRACT
A polysaccharide-rich fraction (ATF) of medicinal mushroom Agaricus brasiliensis was evaluated on the candidacidal activity, H2O2 and nitric oxide (NO) production, and expression of mannose receptors by murine peritoneal macrophages. Mice received three intraperitoneal (i.p.) injections of ATF and after 48 h their peritoneal resident macrophages were assayed against Candida albicans yeast forms. The treatment increased fungicidal activity and it was associated with higher levels of H2O2, whereas NO production was not affected. We also found that the treatment enhances mannose receptor expression by peritoneal macrophages, which are involved in the attachment and phagocytosis of non-opsonized microorganisms. Treatment of animals with ATF was able to enhance the clearance of C. albicans during the first 6 h after the experimental i.p. infection. Our results suggest that this extract can increase host resistance against some infectious agents through the stimulation of microbicidal activity of macrophages.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Polysaccharides / Agaricus / Candida albicans / Macrophages, Peritoneal Limits: Animals Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2008 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Bandeirantes/BR / Universidade Estadual Paulista/BR

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Full text: Available Index: LILACS (Americas) Main subject: Polysaccharides / Agaricus / Candida albicans / Macrophages, Peritoneal Limits: Animals Country/Region as subject: South America / Brazil Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2008 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Universidade Bandeirantes/BR / Universidade Estadual Paulista/BR