Polysaccharide-rich fraction of Agaricus brasiliensis enhances the candidacidal activity of murine macrophages
Mem. Inst. Oswaldo Cruz
;
103(3): 244-250, May 2008. ilus, graf
Article
in English
| LILACS
| ID: lil-485211
ABSTRACT
A polysaccharide-rich fraction (ATF) of medicinal mushroom Agaricus brasiliensis was evaluated on the candidacidal activity, H2O2 and nitric oxide (NO) production, and expression of mannose receptors by murine peritoneal macrophages. Mice received three intraperitoneal (i.p.) injections of ATF and after 48 h their peritoneal resident macrophages were assayed against Candida albicans yeast forms. The treatment increased fungicidal activity and it was associated with higher levels of H2O2, whereas NO production was not affected. We also found that the treatment enhances mannose receptor expression by peritoneal macrophages, which are involved in the attachment and phagocytosis of non-opsonized microorganisms. Treatment of animals with ATF was able to enhance the clearance of C. albicans during the first 6 h after the experimental i.p. infection. Our results suggest that this extract can increase host resistance against some infectious agents through the stimulation of microbicidal activity of macrophages.
Full text:
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Index:
LILACS (Americas)
Main subject:
Polysaccharides
/
Agaricus
/
Candida albicans
/
Macrophages, Peritoneal
Limits:
Animals
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2008
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Bandeirantes/BR
/
Universidade Estadual Paulista/BR
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