Morphological and functional characterizations of Schwann cells stimulated with Mycobacterium leprae
Mem. Inst. Oswaldo Cruz
;
103(4): 363-369, June 2008. ilus, graf, tab
Article
in English
| LILACS
| ID: lil-486874
ABSTRACT
Nerve damage, a characteristic of leprosy, is the cause of patient deformities and a consequence of Schwann cells (SC) infection by Mycobacterium leprae. Although function/dysfunction of SC in human diseases like leprosy is difficult to study, many in vitro models, including SC lines derived from rat and/or human Schwannomas, have been employed. ST88-14 is one of the cell lineages used by many researchers as a model for M. leprae/SC interaction. However, it is necessary to establish the values and limitations of the generated data on the effects of M. leprae in these SC. After evaluating the cell line phenotype in the present study, it is close to non-myelinating SC, making this lineage an ideal model for M. leprae/SC interaction. It was also observed that both M. leprae and PGL-1, a mycobacterial cell-wall component, induced low levels of apoptosis in ST88-14 by a mechanism independent of Bcl-2 family members.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Schwann Cells
/
Glycolipids
/
Apoptosis
/
Mycobacterium leprae
/
Antigens, Bacterial
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2008
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fiocruz/BR
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