Biological evaluation of novel 6-Arylbenzimidazo [1.2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
Biol. Res
;
41(1): 43-50, 2008. ilus, tab
Article
in English
| LILACS
| ID: lil-490631
ABSTRACT
This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents.
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LILACS (Americas)
Main subject:
Quinazolines
/
Tumor Necrosis Factor-alpha
/
Anti-Inflammatory Agents
Limits:
Humans
Language:
English
Journal:
Biol. Res
Journal subject:
Biology
Year:
2008
Type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Pontificia Universidad Católica de Chile/CL
/
Universidad de Chile/CL
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