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Biological evaluation of novel 6-Arylbenzimidazo [1.2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
Galarce, Gloria D; Foncea, Rocío E; Edwards, Ana M; Pessoa-Mahana, Hernán; Pessoa-Mahana, Carlos D; Ebensperger, Roberto A.
  • Galarce, Gloria D; Pontificia Universidad Católica de Chile. Facultad de Química. Departamento de Farmacia. Santiago. CL
  • Foncea, Rocío E; Pontificia Universidad Católica de Chile. Facultad de Medicina. Departamento de Nutrición, Diabetes y Metabolismo. Santiago. CL
  • Edwards, Ana M; Pontificia Universidad Católica de Chile. Facultad de Química. Departamento de Fisicoquímica. Santiago. CL
  • Pessoa-Mahana, Hernán; Universidad de Chile. Facultad de Ciencias Químicas y Farmacéuticas. Departamento de Química Orgánica. Santiago. CL
  • Pessoa-Mahana, Carlos D; Pontificia Universidad Católica de Chile. Facultad de Química. Departamento de Farmacia. Santiago. CL
  • Ebensperger, Roberto A; Pontificia Universidad Católica de Chile. Facultad de Química. Departamento de Farmacia. Santiago. CL
Biol. Res ; 41(1): 43-50, 2008. ilus, tab
Article in English | LILACS | ID: lil-490631
ABSTRACT
This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents.
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Full text: Available Index: LILACS (Americas) Main subject: Quinazolines / Tumor Necrosis Factor-alpha / Anti-Inflammatory Agents Limits: Humans Language: English Journal: Biol. Res Journal subject: Biology Year: 2008 Type: Article Affiliation country: Chile Institution/Affiliation country: Pontificia Universidad Católica de Chile/CL / Universidad de Chile/CL

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Full text: Available Index: LILACS (Americas) Main subject: Quinazolines / Tumor Necrosis Factor-alpha / Anti-Inflammatory Agents Limits: Humans Language: English Journal: Biol. Res Journal subject: Biology Year: 2008 Type: Article Affiliation country: Chile Institution/Affiliation country: Pontificia Universidad Católica de Chile/CL / Universidad de Chile/CL