Embriopatía por isotretinoína: Un daño evitable

Troncoso Sen, Mónica; Rojas H., Carla; Bravo C., Eduardo

Embriopatía por isotretinoína: Un daño evitable / Isotretinoin embryophaty: Report of one case

Troncoso Sen, Mónica; Rojas H., Carla; Bravo C., Eduardo.

Troncoso Sen, Mónica; Universidad de Chile. Facultad de Medicina. Hospital Clínico San Borja. Servicio de Neuropsiquiatría Infantil. Santiago. CL
Rojas H., Carla; Universidad de Chile. Facultad de Medicina. Hospital Clínico San Borja. Servicio de Neuropsiquiatría Infantil. Santiago. CL
Bravo C., Eduardo; Universidad de Chile. Facultad de Medicina. Departamento de Ciencias Neurológicas Oriente. Instituto de Neurocirugía Dr. Asenjo. Santiago. CL

Rev. méd. Chile ; 136(6): 763-766, jun. 2008. ilus

Article in Spanish | LILACS | ID: lil-490763

ABSTRACT

ABSTRACT

Retinoic acid is a widely used drug in the treatment of cystic acné. It has teratogenic effects that depend on the gestational period in which it is used. We report a seven months of female whose mother was exposed to retinoic acid in both pregestational and gestational periods. She had a retardation of psychomotor development and a brain MRI showed frontal atrophy and a malformation of the posterior fossa. We discuss the mechanisms ofthe teratogenic effeets of retinoic acid.

Subject(s)

Female; Humans; Infant; Pregnancy; Abnormalities, Drug-Induced; Abnormalities, Multiple/chemically induced; Craniofacial Abnormalities/chemically induced; Isotretinoin/adverse effects; Keratolytic Agents/adverse effects; Teratogens; Acne Vulgaris/drug therapy; Atrophy/chemically induced; Cranial Fossa, Posterior/abnormalities; Cranial Fossa, Posterior/drug effects; Frontal Lobe/abnormalities; Frontal Lobe/drug effects; Maternal Exposure/adverse effects; Prenatal Exposure Delayed Effects/chemically induced; Psychomotor Disorders/chemically induced; Tretinoin/adverse effects

Abnormalities, drug-induced; Embryonic and fetal development; Tretinoin

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Full text: Available Index: LILACS (Americas) Main subject: Teratogens / Abnormalities, Drug-Induced / Abnormalities, Multiple / Isotretinoin / Craniofacial Abnormalities / Keratolytic Agents Limits: Female / Humans / Infant / Pregnancy Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 2008 Type: Article Affiliation country: Chile Institution/Affiliation country: Universidad de Chile/CL

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