Effects of prenatal stress on male offspring sexual maturity
Biocell
;
31(1): 67-74, abr. 2007. tab, graf
Article
in English
| LILACS
| ID: lil-491531
ABSTRACT
Prenatal stimulations have been shown to have long-term effects on at reproductive activity. We evaluated the influence of the prenatal stress on the hypothalamic-pituitary-gonad (HPG) axis in male offsprings from mothers with high number of offsprings per litter (HNL) and low number of offsprings per litter (LNL) after hypothesizing that the number of offsprings per litter may modify the effect of the prenatal stress on the HPG of adult offsprings. Pregnant Wistar rats were used for this study. Immobilization (IMO) stress was used, 30 min, 3 times per week, from the 5th to 21st day of pregnancy. The weight of adrenal and gonads, and the corticosterone (COR), testosterone (TES) and luteinizing hormone (LH) plasmatic levels were analyzed in the male offspring at 30, 45 and 70 days of age. The offspring males coming from LNL showed a decrease in testicle weight and TES levels, without changes in the plasmatic LH levels. However, the offspring of HNL showed a decrease of LH levels. It is possible to conclude that in LNL prenatal stress would produce alterations to gonadal level, while in HNL the effect of stress would be evident at pituitary level.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Pituitary Gland
/
Sexual Maturation
/
Stress, Physiological
/
Testis
/
Corticosterone
/
Luteinizing Hormone
/
Hypothalamus
Type of study:
Etiology study
Limits:
Animals
/
Pregnancy
Language:
English
Journal:
Biocell
Journal subject:
Clulas
Year:
2007
Type:
Article
Affiliation country:
Argentina
Institution/Affiliation country:
Universidad Nacional de Río Cuarto/AR
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