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Terapia antiretroviral en pacientes con VIH: una respuesta inesperada / Antiretroviral therapy in HIV infected patients: an unexpected response
Apablaza, Pamela; Espinoza, Danay; Bahamondes, Laura.
  • Apablaza, Pamela; Universidad de Santiago de Chile. Facultad de Ciencias Médicas. CL
  • Espinoza, Danay; Universidad de Santiago de Chile. Facultad de Ciencias Médicas. CL
  • Bahamondes, Laura; Hospital de Enfermedades Infecciosas Doctor Lucio Córdova. Santiago. CL
Clin. cienc ; 3(1): 23-32, 2006. tab
Article in Spanish | LILACS | ID: lil-491731
RESUMEN
En relación al uso de terapia antiretroviral (TAR) en pacientes con VIH, se ha descrito un síndrome clínico tras el inicio o cambio de la terapia, denominado Síndrome de Reconstitución Inmune (SRI). Se trata de un cuadro caracterizado por el deterioro inesperado en el estado clínico de los pacientes, producto de una respuesta inflamatoria exagerada en contra de patógenos oportunistas, tumores o antígenos propios del paciente. El manejo del SRI, incluye uso de antimicrobianos específicos y/o terapia antiinflamatoria, sin ser necesaria la descontinuación de la TAR. Es prioritario en la investigación del SRI, el desarrollo de estrategias de prevención, métodos de pesquisa de factores de riesgo y criterios diagnósticos.
ABSTRACT
Related to the antiretroviral therapy in HIV infected persons, it has been described a clinical syndrome called the Immune Restoration Disease (IRD). It appears after the initiation or switching of the therapy and is characterized by an exaggerated inflammatory response after the improvement of the immune system, which leads to an unexpected worsening of the clinical condition of the patient. This inflammatory response is presented against opportunist pathogens, tumors or the patient’s own antigens. The management of IRD often requires the use of anti-microbial and/or anti-inflammatory therapy, without interruption of the antiretroviral therapy. It is a priority for future research, to develop strategies to prevent IRD, risk assessment methods and diagnostic criteria.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: HIV Infections / AIDS-Related Opportunistic Infections / Anti-Retroviral Agents / Immune System Diseases Type of study: Risk factors Limits: Humans Language: Spanish Journal: Clin. cienc Journal subject: Internal Medicine Year: 2006 Type: Article Affiliation country: Chile Institution/Affiliation country: Hospital de Enfermedades Infecciosas Doctor Lucio Córdova/CL / Universidad de Santiago de Chile/CL

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Full text: Available Index: LILACS (Americas) Main subject: HIV Infections / AIDS-Related Opportunistic Infections / Anti-Retroviral Agents / Immune System Diseases Type of study: Risk factors Limits: Humans Language: Spanish Journal: Clin. cienc Journal subject: Internal Medicine Year: 2006 Type: Article Affiliation country: Chile Institution/Affiliation country: Hospital de Enfermedades Infecciosas Doctor Lucio Córdova/CL / Universidad de Santiago de Chile/CL