Your browser doesn't support javascript.
loading
Increased oxidative stress as a mechanism for decreased BDNF levels in acute manic episodes / Aumento do estresse oxidativo como um mecanismo para a diminuição dos níveis de BDNF em episódios maníacos agudos
Kapczinski, Flávio; Frey, Benício N; Andreazza, Ana C; Kauer-Sant'Anna, Márcia; Cunha, Ângelo B M; Post, Robert M.
  • Kapczinski, Flávio; Hospital de Clínicas de Porto Alegre. Bipolar Disorders Program and Laboratory of Molecular Psychiatry. Porto Alegre. BR
  • Frey, Benício N; McMaster University. Department of Psychiatry and Behavioural Neurosciences. Hamilton. CA
  • Andreazza, Ana C; Hospital de Clínicas de Porto Alegre. Bipolar Disorders Program and Laboratory of Molecular Psychiatry. Porto Alegre. BR
  • Kauer-Sant'Anna, Márcia; Hospital de Clínicas de Porto Alegre. Bipolar Disorders Program and Laboratory of Molecular Psychiatry. Porto Alegre. BR
  • Cunha, Ângelo B M; Universidade Federal de Santa Maria. Centro de Ciências da Saúde. Department of Neuropsychiatry. Santa Maria. BR
  • Post, Robert M; Penn State College of Medicine. Chevy Chase. US
Braz. J. Psychiatry (São Paulo, 1999, Impr.) ; 30(3): 243-245, set. 2008. graf, tab
Article in English | LILACS | ID: lil-493779
ABSTRACT
OBJECTIVE AND

METHOD:

There is a growing amount of data indicating that alterations in brain-derived neurotrophic factor and increased oxidative stress may play a role in the pathophysiology of bipolar disorder. In light of recent evidence demonstrating that brain-derived neurotrophic factor levels are decreased in situations of increased oxidative stress, we have examined the correlation between serum thiobarbituric acid reactive substances, a measure of lipid peroxidation, and serum brain-derived neurotrophic factor levels in bipolar disorder patients during acute mania and in healthy controls.

RESULTS:

Serum thiobarbituric acid reactive substances and brain-derived neurotrophic factor levels were negatively correlated in bipolar disorder patients (r = -0.56; p = 0.001), whereas no significant correlation was observed in the control group..

CONCLUSION:

These results suggest that alterations in oxidative status may be mechanistically associated with abnormal low levels of brain-derived neurotrophic factor observed in individuals with bipolar disorder.
RESUMO
OBJETIVO E

MÉTODO:

Existem crescentes evidências indicando que alterações no fator neurotrófico derivado do cérebro e aumento do estresse oxidativo podem estar envolvidos na fisiopatologia do transtorno bipolar. Considerando os achados recentes de que os níveis de fator neurotrófico derivado do cérebro estão diminuídos em situações de aumento de estresse oxidativo, nós testamos a correlação entre os níveis séricos de substâncias reativas do ácido tiobarbitúrico, um índice de peroxidação lipídica, e os níveis séricos de fator neurotrófico derivado do cérebro em pacientes portadores de transtorno bipolar durante mania aguda e em controles saudáveis.

RESULTADOS:

Os níveis séricos de substâncias reativas do ácido tiobarbitúrico e fator neurotrófico derivado do cérebro apresentaram uma correlação negativa em pacientes bipolares (r = -0,56; p = 0,001), enquanto não houve correlação significativa no grupo controle.

CONCLUSÃO:

Estes resultados sugerem que alterações de estresse oxidativo podem ser mecanisticamente associadas com níveis reduzidos de BDNF observados em indivíduos com transtorno bipolar.
Subject(s)

Full text: Available Index: LILACS (Americas) Main subject: Bipolar Disorder / Oxidative Stress / Brain-Derived Neurotrophic Factor Type of study: Observational study / Risk factors Limits: Female / Humans / Male Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2008 Type: Article Affiliation country: Brazil / Canada / United States Institution/Affiliation country: Hospital de Clínicas de Porto Alegre/BR / McMaster University/CA / Penn State College of Medicine/US / Universidade Federal de Santa Maria/BR

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: LILACS (Americas) Main subject: Bipolar Disorder / Oxidative Stress / Brain-Derived Neurotrophic Factor Type of study: Observational study / Risk factors Limits: Female / Humans / Male Language: English Journal: Braz. J. Psychiatry (São Paulo, 1999, Impr.) Journal subject: Psychiatry Year: 2008 Type: Article Affiliation country: Brazil / Canada / United States Institution/Affiliation country: Hospital de Clínicas de Porto Alegre/BR / McMaster University/CA / Penn State College of Medicine/US / Universidade Federal de Santa Maria/BR