Hip fracture risk and different gene polymorphisms in the turkish population
Clinics
;
63(5): 645-650, 2008. tab
Article
in English
| LILACS
| ID: lil-495040
ABSTRACT
BACKGROUND:
We aimed to discuss the risk assessments for both patients with hip fractures due to fall-related, low energy traumas and non-fractured control patients by examining bone mineral density and genetic data, two features associated with femoral strength and hip fracture risk.METHODS:
Twenty-one osteoporotic patients with proximal femur fractures and non-fractured, osteoporotic, age- and gender-matched controls were included in the study. Bone mineral density measurements were performed with a Lunar DXA. The COL1A1, ESR, VDR, IL-6, and OPG genes were amplified, and labeling of specific gene sequences was performed in a multiplex polymerase chain reaction using the osteo/check PCR kit from the whole blood of all subjects.RESULTS:
The bone mineral density (trochanteric and total bone mineral density values) of the fracture group was significantly decreased relative to the control group. We were not able to conduct statistical tests for the polymorphisms of the COL1A1, ESR, and VDR genes because our results were expressed in terms of frequency. Although they were not significant, we did examine differences in the IL-6 and OPG genes polymorphisms between the two groups. We concluded that increasing the number of cases will allow us to evaluate racial differences in femoral hip fracture risk by genotypes.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Bone Density
/
Collagen Type I
/
Estrogen Receptor alpha
/
Osteoprotegerin
/
Hip Fractures
Type of study:
Etiology study
/
Observational study
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Clinics
Journal subject:
Medicine
Year:
2008
Type:
Article
/
Project document
Affiliation country:
Turkey
Institution/Affiliation country:
Ankara Training and Research Hospital/TR
/
Gazi University/TR
Similar
MEDLINE
...
LILACS
LIS