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Characterization of the 3-HKT gene in important malaria vectors in India, viz: Anopheles culicifacies and Anopheles stephensi (Diptera: Culicidae)
Vidhyanandhini, R; Kumar, N. Pradeep.
  • Vidhyanandhini, R; Indian Council of Medical Research. Medical Complex. Vector Control Research Centre. Pondicherry. IN
  • Kumar, N. Pradeep; Indian Council of Medical Research. Medical Complex. Vector Control Research Centre. Pondicherry. IN
Mem. Inst. Oswaldo Cruz ; 103(6): 595-597, Sept. 2008. ilus, tab
Article in English | LILACS | ID: lil-495735
ABSTRACT
The 3-hydroxykynurenine transaminase (3-HKT) gene plays a vital role in the development of malaria parasites by participating in the synthesis of xanthurenic acid, which is involved in the exflagellation of microgametocytes in the midgut of malaria vector species. The 3-HKT enzyme is involved in the tryptophan metabolism of Anophelines. The gene had been studied in the important global malaria vector, Anopheles gambiae. In this report, we have conducted a preliminary investigation to characterize this gene in the two important vector species of malaria in India, Anopheles culicifacies and Anopheles stephensi. The analysis of the genetic structure of this gene in these species revealed high homology with the An. gambiae gene. However, four non-synonymous mutations in An. stephensi and seven in An. culicifacies sequences were noted in the exons 1 and 2 of the gene; the implication of these mutations on enzyme structure remains to be explored.
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Full text: Available Index: LILACS (Americas) Main subject: Transaminases / Insect Vectors / Anopheles / Mutation Limits: Animals Country/Region as subject: Asia Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2008 Type: Article Affiliation country: India Institution/Affiliation country: Indian Council of Medical Research/IN

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Full text: Available Index: LILACS (Americas) Main subject: Transaminases / Insect Vectors / Anopheles / Mutation Limits: Animals Country/Region as subject: Asia Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2008 Type: Article Affiliation country: India Institution/Affiliation country: Indian Council of Medical Research/IN